Prevalence ofHFEC282Y and H63D genotypes according to race or ethnic group.*
| . | . | C282Y/C282Y . | C282Y/H63D . | H63D/H63D . | C282Y/+ . | H63D/+ . | +/+ . | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Race or ethnic group . | Total no. of participants . | No. . | Prevalence, % (95% CI) . | No. . | Prevalence, % (95% CI) . | No. . | Prevalence, % (95% CI) . | No. . | Prevalence, % (95% CI) . | No. . | Prevalence, % (95% CI) . | No. . | Prevalence, % (95% CI) . |
| *All participants with complete data on HFE C282Y and H63D mutations, TfS, and SF levels are included, with the exception of 1457 participants who reported hearing about the study exclusively from a participating family member. Rates of prevalence were derived with Hardy-Weinberg proportions in the five groups of participants not homozygous for the C282Y mutation within each racial or ethnic group. Race or ethnic group was self-reported. | |||||||||||||
| CI indicates confidence interval. | |||||||||||||
| Reprinted with permission from Adams PC et al. N Engl J Med. 2005;352:1769–1778. 29 | |||||||||||||
| White | 44,082 | 281 | 0.44 (0.42–0.47) | 908 | 2.0 (2.0–2.1) | 1029 | 2.4 (2.3–2.4) | 4548 | 10 (10–11) | 10,537 | 24 (24–24) | 26,779 | 61 (60–61) |
| Native American | 648 | 1 | 0.11 (0.061–0.20) | 7 | 0.77 (0.56–1.1) | 7 | 1.3 (0.98–1.8) | 35 | 5.7 (4.2–7.7) | 128 | 20 (17–22) | 470 | 72 (69–76) |
| Hispanic | 12,459 | 7 | 0.027 (0.022–0.032) | 48 | 0.33 (0.30–0.37) | 154 | 1.1 (0.98–1.1) | 351 | 2.9 (2.6–3.2) | 2199 | 18 (18–19) | 9700 | 78 (77–78) |
| Black | 27,124 | 4 | 0.014 (0.012–0.017) | 35 | 0.071 (0.065–0.078) | 30 | 0.089 (0.081–0.097) | 605 | 2.3 (2.1–2.5) | 1520 | 5.7 (5.4–6.0) | 24,930 | 92 (92–92) |
| Pacific Islander | 698 | 0 | 0.012 (0.0043–0.032) | 0 | 0.096 (0.055–0.17) | 0 | 0.20 (0.12–0.32) | 15 | 2.0 (1.2–3.4) | 62 | 8.4 (6.6–11) | 621 | 89 (87–91) |
| Asian | 12,772 | 0 | 0.000039 (0.000015–0.0001) | 0 | 0.0055 (0.0029–0.0093) | 29 | 0.20 (0.17–0.22) | 16 | 0.12 (0.074–0.19) | 1070 | 8.4 (8.0–8.9) | 11,657 | 91 (91–92) |
| Multiple/unknown | 1928 | 6 | — | 19 | — | 21 | — | 111 | — | 313 | — | 1458 | — |
| All | 99,711 | 299 | — | 1017 | — | 1270 | — | 5681 | — | 15,829 | — | 75,615 | — |
| . | . | C282Y/C282Y . | C282Y/H63D . | H63D/H63D . | C282Y/+ . | H63D/+ . | +/+ . | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Race or ethnic group . | Total no. of participants . | No. . | Prevalence, % (95% CI) . | No. . | Prevalence, % (95% CI) . | No. . | Prevalence, % (95% CI) . | No. . | Prevalence, % (95% CI) . | No. . | Prevalence, % (95% CI) . | No. . | Prevalence, % (95% CI) . |
| *All participants with complete data on HFE C282Y and H63D mutations, TfS, and SF levels are included, with the exception of 1457 participants who reported hearing about the study exclusively from a participating family member. Rates of prevalence were derived with Hardy-Weinberg proportions in the five groups of participants not homozygous for the C282Y mutation within each racial or ethnic group. Race or ethnic group was self-reported. | |||||||||||||
| CI indicates confidence interval. | |||||||||||||
| Reprinted with permission from Adams PC et al. N Engl J Med. 2005;352:1769–1778. 29 | |||||||||||||
| White | 44,082 | 281 | 0.44 (0.42–0.47) | 908 | 2.0 (2.0–2.1) | 1029 | 2.4 (2.3–2.4) | 4548 | 10 (10–11) | 10,537 | 24 (24–24) | 26,779 | 61 (60–61) |
| Native American | 648 | 1 | 0.11 (0.061–0.20) | 7 | 0.77 (0.56–1.1) | 7 | 1.3 (0.98–1.8) | 35 | 5.7 (4.2–7.7) | 128 | 20 (17–22) | 470 | 72 (69–76) |
| Hispanic | 12,459 | 7 | 0.027 (0.022–0.032) | 48 | 0.33 (0.30–0.37) | 154 | 1.1 (0.98–1.1) | 351 | 2.9 (2.6–3.2) | 2199 | 18 (18–19) | 9700 | 78 (77–78) |
| Black | 27,124 | 4 | 0.014 (0.012–0.017) | 35 | 0.071 (0.065–0.078) | 30 | 0.089 (0.081–0.097) | 605 | 2.3 (2.1–2.5) | 1520 | 5.7 (5.4–6.0) | 24,930 | 92 (92–92) |
| Pacific Islander | 698 | 0 | 0.012 (0.0043–0.032) | 0 | 0.096 (0.055–0.17) | 0 | 0.20 (0.12–0.32) | 15 | 2.0 (1.2–3.4) | 62 | 8.4 (6.6–11) | 621 | 89 (87–91) |
| Asian | 12,772 | 0 | 0.000039 (0.000015–0.0001) | 0 | 0.0055 (0.0029–0.0093) | 29 | 0.20 (0.17–0.22) | 16 | 0.12 (0.074–0.19) | 1070 | 8.4 (8.0–8.9) | 11,657 | 91 (91–92) |
| Multiple/unknown | 1928 | 6 | — | 19 | — | 21 | — | 111 | — | 313 | — | 1458 | — |
| All | 99,711 | 299 | — | 1017 | — | 1270 | — | 5681 | — | 15,829 | — | 75,615 | — |