Hereditary iron overload conditions in which anemia is not a prominent feature.
| Condition (gene) . | Chromosomal location . | Inheritance pattern . | Population affected . | Relative frequency . | Mechanism . |
|---|---|---|---|---|---|
| HFE-hemochromatosis (HFE) | 6p21 | Autosomal recessive | Caucasion | Common | Decreased hepcidin production |
| Transferrin receptor 2 hemochromatosis (TfR2) | 7q22 | Autosomal recessive | Italian, ?others | Rare | Decreased hepcidin production |
| Juvenile hemochromatosis (HJV) | 1q21 | Autosomal recessive | Caucasian, others | Rare | Decreased hepcidin production |
| Juvenile hemochromatosis (HAMP) | 19q13 | Autosomal recessive | Caucasian, others | Rare | Decreased hepcidin production |
| Ferroportin disease (SLC40A1) | 2q32 | Autosomal dominant | Caucasian, others | ? | Resistance to hepcidin |
| Condition (gene) . | Chromosomal location . | Inheritance pattern . | Population affected . | Relative frequency . | Mechanism . |
|---|---|---|---|---|---|
| HFE-hemochromatosis (HFE) | 6p21 | Autosomal recessive | Caucasion | Common | Decreased hepcidin production |
| Transferrin receptor 2 hemochromatosis (TfR2) | 7q22 | Autosomal recessive | Italian, ?others | Rare | Decreased hepcidin production |
| Juvenile hemochromatosis (HJV) | 1q21 | Autosomal recessive | Caucasian, others | Rare | Decreased hepcidin production |
| Juvenile hemochromatosis (HAMP) | 19q13 | Autosomal recessive | Caucasian, others | Rare | Decreased hepcidin production |
| Ferroportin disease (SLC40A1) | 2q32 | Autosomal dominant | Caucasian, others | ? | Resistance to hepcidin |