Current interpretation of data regarding the ability of biomarkers to predict response to purine nucleoside analogues (PNA) and alkylating agents ± rituximab.
| Prognostic factor . | Predicts poor response to PNA & alkylating agents ± rituximab . | Predicts shorter PFS/OS after treatment with PNA & alkylating agents ± rituximab . | Selected References . |
|---|---|---|---|
| del(17p13) or TP53 defects | Yes | Yes | Marker as predictor of response: |
| Support: 36,39,40,49 –52 | |||
| Against: 45,53 | |||
| Marker as predictor of PFS/OS: | |||
| Support: 36,39,40,45,50 –53 | |||
| del(11q22) | Yes/No | Yes | Marker as predictor of response: |
| Support: 39 | |||
| Against: 45,50,52,53 | |||
| Marker as predictor of PFS/OS: | |||
| Support: 39,45,53 | |||
| Against: 50,52 | |||
| Unmutated IGHV | No | Yes | Marker as predictor of response: |
| Against: 46,50,53,54 | |||
| Marker as predictor of PFS/OS: | |||
| Support: 39,40,45,46,52,54,55 | |||
| Against: 50,53 | |||
| ZAP-70+ | No | Yes/No | Marker as predictor of response: |
| Support: 52 | |||
| Against: 50,53,54 | |||
| Marker as predictor of PFS/OS: | |||
| Support: 52,55 | |||
| Against: 50,53,54 | |||
| CD38+ | No | No | Marker as predictor of response: |
| Against 50,53,54 | |||
| Marker as predictor of PFS/OS: | |||
| Support: 55 | |||
| Against: 50,52 –54 |
| Prognostic factor . | Predicts poor response to PNA & alkylating agents ± rituximab . | Predicts shorter PFS/OS after treatment with PNA & alkylating agents ± rituximab . | Selected References . |
|---|---|---|---|
| del(17p13) or TP53 defects | Yes | Yes | Marker as predictor of response: |
| Support: 36,39,40,49 –52 | |||
| Against: 45,53 | |||
| Marker as predictor of PFS/OS: | |||
| Support: 36,39,40,45,50 –53 | |||
| del(11q22) | Yes/No | Yes | Marker as predictor of response: |
| Support: 39 | |||
| Against: 45,50,52,53 | |||
| Marker as predictor of PFS/OS: | |||
| Support: 39,45,53 | |||
| Against: 50,52 | |||
| Unmutated IGHV | No | Yes | Marker as predictor of response: |
| Against: 46,50,53,54 | |||
| Marker as predictor of PFS/OS: | |||
| Support: 39,40,45,46,52,54,55 | |||
| Against: 50,53 | |||
| ZAP-70+ | No | Yes/No | Marker as predictor of response: |
| Support: 52 | |||
| Against: 50,53,54 | |||
| Marker as predictor of PFS/OS: | |||
| Support: 52,55 | |||
| Against: 50,53,54 | |||
| CD38+ | No | No | Marker as predictor of response: |
| Against 50,53,54 | |||
| Marker as predictor of PFS/OS: | |||
| Support: 55 | |||
| Against: 50,52 –54 |