ICUS Definition (3 components)Meaningful cytopenias (hemoglobin < 11 g/dL, absolute neutrophil count < 1500/mm3, or platelets < 100 × 109/L) lasting more than 6 months Does not meet minimal diagnostic criteria for MDS (see below) Other recognized causes of cytopenias have been excluded (see below) |
Minimal Diagnostic Criteria for MDS—both “prerequisite” criteria, plus at least one “decisive” criterion or preponderance of co-criteria |
“Required” Investigations to Exclude Other Causes of CytopeniasDetailed case history (toxins, drugs, mutagenic events, etc) Thorough clinical investigations, including X-ray or sonography of spleen Differential blood count (microscopic) and complete serum chemistry Bone marrow smear, histology and immunohistochemistry Flow cytometry of bone marrow and peripheral blood cells Chromosome analysis including FISH Molecular analysis where appropriate (for example, T-cell receptor rearrangement for neutropenia) Exclusion of viral infections (HCV, HIV, CMV, EBV, others) |