Table 1. Evaluation of published reports... | American Society of Hematology

Table 1.

Evaluation of published reports on drug-induced thrombocytopenia.

Adapted from www.ouhsc.edu/platelets.
*Criteria for non-evaluable data: insufficient patient data in the report; platelet count not <100,000/μL; cytotoxic drug, marrow suppression; non-therapeutic agent or used in non-therapeutic manner; drug-induced disease in addition to thrombocytopenia; patient age <16 years.
Criteria for evaluation of individual patient data
Drug administration preceded thrombocytopenia; recovery from thrombocytopenia complete and sustained after drug discontinued Other drugs administered prior to thrombocytopenia were continued or reintroduced after discontinuation of the suspected drug Other etiologies of thrombocytopenia excluded Re-exposure to the drug resulted in recurrent thrombocytopenia
Levels of evidence Definite: all 4 criteria met Probable: Criteria 1–3 met Possible: Criterion 1 met Unlikely: Criterion 1 not met Data not evaluable*
Criteria for evaluation of group data
Levels of evidence Definite: randomized controlled clinical trial demonstrating significantly greater frequency of thrombocytopenia in the drug administration group Probable: non-randomized clinical trial demonstrating greater frequency of thrombocytopenia in the drug administration group Possible: case series without controls reporting thrombocytopenia associated with drug administration Data not evaluable*