Age-adjusted dose reduction.
| . | 65–75 years . | >75 years . | Further dose reduction . |
|---|---|---|---|
| Dexamethasone weekly | 40 mg | 20 mg | 10 mg |
| Melphalan days 1–4 | 0.25 mg/kg | 0.18 mg/kg | 0.13 mg/kg |
| Thalidomide per day | 200 mg | 100 mg | 50 mg |
| Lenalidomide (in combination with dexamethasone) days 1–21 | 25 mg | 15 mg | 10 mg |
| Lenalidomide (in combination with melphalan plus prednisone) days 1–21 | 10 mg | 5 mg | 5 mg every other day |
| Bortezomib | 1.3 mg/m2 twice-weekly | 1.3 mg/m2 weekly | 1.0 mg/m2 weekly |
| . | 65–75 years . | >75 years . | Further dose reduction . |
|---|---|---|---|
| Dexamethasone weekly | 40 mg | 20 mg | 10 mg |
| Melphalan days 1–4 | 0.25 mg/kg | 0.18 mg/kg | 0.13 mg/kg |
| Thalidomide per day | 200 mg | 100 mg | 50 mg |
| Lenalidomide (in combination with dexamethasone) days 1–21 | 25 mg | 15 mg | 10 mg |
| Lenalidomide (in combination with melphalan plus prednisone) days 1–21 | 10 mg | 5 mg | 5 mg every other day |
| Bortezomib | 1.3 mg/m2 twice-weekly | 1.3 mg/m2 weekly | 1.0 mg/m2 weekly |