Current treatment results for acute myeloid leukemia (AML) in the older adult.
| Study . | N . | Ind/Consol . | CR (%) . | ED (%) . | OS (2–7 yr.) (%) . |
|---|---|---|---|---|---|
| Abbreviations: CR, Complete Remission; ED, Early Death; OS, Overall Survival; CALGB, Cancer and Leukemia Group B; ECOG, Eastern Cooperative Oncology Group; SWOG, Southwest Oncology Group; MRC, Medical Research Council; Ind, Induction; Consol, Consolidation; D, daunorubicin; A, cytarabine; M, mitoxantrone; MA, mitoxantrone, cytarabine; I, idarubicin; ME, mitoxantrone etoposide; DA, daunorubicin, cytarabine; DAT, daunorubicin, cytarabine, 6-thioguanine; ADE, daunorubicin, cytarabine, etoposide; MAC, mitoxantrone, cytarabine; COAP, cyclophosphamide, vincristine, cytarabine, prednisone | |||||
| CALGB | 388 | DA/A or MA | 52 | 25 | 15 |
| ECOG | 348 | D or I or M (each) + A/A | 42 | 17 | 10 |
| SWOG | 328 | DA or ME/DA | 43 | 7 | 19 |
| MRC | 1314 | DAT or ADE or MAC/DAT or COAP, DAT, COAP | 55 | 19 | 10 |
| Study . | N . | Ind/Consol . | CR (%) . | ED (%) . | OS (2–7 yr.) (%) . |
|---|---|---|---|---|---|
| Abbreviations: CR, Complete Remission; ED, Early Death; OS, Overall Survival; CALGB, Cancer and Leukemia Group B; ECOG, Eastern Cooperative Oncology Group; SWOG, Southwest Oncology Group; MRC, Medical Research Council; Ind, Induction; Consol, Consolidation; D, daunorubicin; A, cytarabine; M, mitoxantrone; MA, mitoxantrone, cytarabine; I, idarubicin; ME, mitoxantrone etoposide; DA, daunorubicin, cytarabine; DAT, daunorubicin, cytarabine, 6-thioguanine; ADE, daunorubicin, cytarabine, etoposide; MAC, mitoxantrone, cytarabine; COAP, cyclophosphamide, vincristine, cytarabine, prednisone | |||||
| CALGB | 388 | DA/A or MA | 52 | 25 | 15 |
| ECOG | 348 | D or I or M (each) + A/A | 42 | 17 | 10 |
| SWOG | 328 | DA or ME/DA | 43 | 7 | 19 |
| MRC | 1314 | DAT or ADE or MAC/DAT or COAP, DAT, COAP | 55 | 19 | 10 |