Current treatment results for acute myeloid leukemia (AML) in younger adults.
| Study . | N . | Ind/Consol . | CR (%) . | ED (%) . | OS (3–5 yr.) (%) . |
|---|---|---|---|---|---|
| Abbreviations: CR, complete remission; ED, early death; OS, overall survival; CALGB, Cancer and Leukemia Group B; GAMLCG, German Cooperative Acute Myeloid Leukemia Group; HOVON, Dutch-Belgian Cooperative Oncology Group; ALFA, Acute Leukemia French Association; Ind, Induction; Consol, Consolidation; D, daunorubicin; A, cytarabine; HiDAC, high-dose ara-C; E, etoposide; CTX, cyclophosphamide; M, mitoxantrone; TAD, 6-thioguanine, cytarabine, daunorubicin; HAM, high-dose ara-c + mitoxantrone; AMGA/A, amsacrine/cytarabine; MEC, mitoxantrone, etoposide, cytarabine; ME, mitoxantrone, etoposide | |||||
| CALGB | 474 | DA/HiDACx3 or HiDACx1, E, CTX or diaziquone, M | 72 | 9 | 34 |
| GAMLCG | 535 | TAD, HAM/TAD | 74 | 11 | 39 |
| HOVON | 253 | DA, AMSA/A/ME | 77 | 7 | 38 |
| ALFA | 345 | DA +/− MA/AMSA/A; MEC | 82 | 9 | 38 |
| Study . | N . | Ind/Consol . | CR (%) . | ED (%) . | OS (3–5 yr.) (%) . |
|---|---|---|---|---|---|
| Abbreviations: CR, complete remission; ED, early death; OS, overall survival; CALGB, Cancer and Leukemia Group B; GAMLCG, German Cooperative Acute Myeloid Leukemia Group; HOVON, Dutch-Belgian Cooperative Oncology Group; ALFA, Acute Leukemia French Association; Ind, Induction; Consol, Consolidation; D, daunorubicin; A, cytarabine; HiDAC, high-dose ara-C; E, etoposide; CTX, cyclophosphamide; M, mitoxantrone; TAD, 6-thioguanine, cytarabine, daunorubicin; HAM, high-dose ara-c + mitoxantrone; AMGA/A, amsacrine/cytarabine; MEC, mitoxantrone, etoposide, cytarabine; ME, mitoxantrone, etoposide | |||||
| CALGB | 474 | DA/HiDACx3 or HiDACx1, E, CTX or diaziquone, M | 72 | 9 | 34 |
| GAMLCG | 535 | TAD, HAM/TAD | 74 | 11 | 39 |
| HOVON | 253 | DA, AMSA/A/ME | 77 | 7 | 38 |
| ALFA | 345 | DA +/− MA/AMSA/A; MEC | 82 | 9 | 38 |