Proposed diagnostic criteria for polycythemia vera (PV).
| a These hematocrit values are invariably associated with a raised red cell mass in an adult population. | |
| b Note that it is possible in rare cases for PV to coexist with a cause of secondary erythrocytosis. | |
| A1. | Raised red cell mass (> 25% above predicted, or hematocrit ≥ 0.60 in males or > 0.56 in females)a |
| A2. | Absence of causes of secondary erythrocytosis (normal arterial oxygen saturation and no elevation of serum erythropoietin.)b |
| A3. | Palpable splenomegaly |
| A4. | Presence of JAK2 V617F mutation or other cytogenetic abnormality (excluding BCR-ABL) in hemopoietic cells |
| B1. | Thrombocytosis (platelets > 400 x 109/L) |
| B2. | Neutrophilia (neutrophils > 10 x 109/L; > 12.5 x 109/L in smokers) |
| B3. | Radiological splenomegaly |
| B4. | Endogenous erythroid colonies or low serum erythropoietin |
| A1 + A2 + either another A or two B criteria is required for a diagnosis of PV | |
| a These hematocrit values are invariably associated with a raised red cell mass in an adult population. | |
| b Note that it is possible in rare cases for PV to coexist with a cause of secondary erythrocytosis. | |
| A1. | Raised red cell mass (> 25% above predicted, or hematocrit ≥ 0.60 in males or > 0.56 in females)a |
| A2. | Absence of causes of secondary erythrocytosis (normal arterial oxygen saturation and no elevation of serum erythropoietin.)b |
| A3. | Palpable splenomegaly |
| A4. | Presence of JAK2 V617F mutation or other cytogenetic abnormality (excluding BCR-ABL) in hemopoietic cells |
| B1. | Thrombocytosis (platelets > 400 x 109/L) |
| B2. | Neutrophilia (neutrophils > 10 x 109/L; > 12.5 x 109/L in smokers) |
| B3. | Radiological splenomegaly |
| B4. | Endogenous erythroid colonies or low serum erythropoietin |
| A1 + A2 + either another A or two B criteria is required for a diagnosis of PV | |