Table 1. Platelet antigens most often... | American Society of Hematology

Table 1.

Platelet antigens most often associated with neonatal alloimmune thrombocytopenia (NAIT).

Platelet Antigen	Alternative Name	Gene Frequency	Comments
HPA-1a	Pl^A1, Zw^a	0.85	Responsible for 75% of clinically significant NAIT in Caucasian population⁶
HPA-3a	Bak^a, Lek^a	0.63	Clinically significant NAIT in Caucasian population⁷
HPA-4a	Pen^a, Yuk^a	0.99	Severe disease in Asian population, rarely Caucasian⁸
HPA-5a	Br^b, Hc^b, Zav^b	0.89	Causes mild NAIT in Caucasian population⁴^,⁹
HPA-5b	Br^a, Hc^a, Zav^a	0.10	In Caucasian population⁶

Platelet Antigen	Alternative Name	Gene Frequency	Comments
HPA-1a	Pl^A1, Zw^a	0.85	Responsible for 75% of clinically significant NAIT in Caucasian population⁶
HPA-3a	Bak^a, Lek^a	0.63	Clinically significant NAIT in Caucasian population⁷
HPA-4a	Pen^a, Yuk^a	0.99	Severe disease in Asian population, rarely Caucasian⁸
HPA-5a	Br^b, Hc^b, Zav^b	0.89	Causes mild NAIT in Caucasian population⁴^,⁹
HPA-5b	Br^a, Hc^a, Zav^a	0.10	In Caucasian population⁶