Proband’s condition should be life-threatening

Insure that the risk of donor-child is not increased to benefit the recipient.

Risk or burden to the donor-child should be limited until the child can decide for self.

Consider independent psychological evaluation prior to IVF and PGD to determine the couple’s ability to rear the child lovingly and without exploitation.

Prior to any invasive harvesting (marrow or organ harvest), donor child should have an independent physician advocate, and there should be an ethics review. Further, consider psychological evaluation of the parents and donor child to any invasive tissue harvesting.

Research protections should apply to the ‘stacked technologies’ of IVF, PGD and HSCT.