Overall approach to primary treatment of Hodgkin lymphoma,
| Stage . | Bulk‡ . | IPFP score . | Treatment . |
|---|---|---|---|
| ‡ Bulk, low < 10 cm, high ≥ 10 cm largest diameter of any single mass | |||
| * ABVD x 4 if CR after 2 cycles, ABVD x 2 + IFRT if < CR after 2 cycles | |||
| **Escalated BEACOPP if IPFP score 4–7 and age less than 60 years | |||
| Abbreviations: ABVD, doxorubicin, bleomycin, vinblastine and dacarbazine; CR, complete response; IFRT, involved field radiotherapy; min, minimum; max, maximum. | |||
| IA, IIA | Low | Not applicable | ABVD x 4 or ABVD x 2 + IFRT* |
| Any stage with B symptoms or III or IV | Low | 0–3 | ABVD until 2 cycles past CR (min 6, max 8) |
| Any stage with B symptoms or III or IV | Low | 4–7 | Intensified chemotherapy** |
| Any stage | High | 0–7 | Chemotherapy as above followed by IFRT to the bulky site |
| Stage . | Bulk‡ . | IPFP score . | Treatment . |
|---|---|---|---|
| ‡ Bulk, low < 10 cm, high ≥ 10 cm largest diameter of any single mass | |||
| * ABVD x 4 if CR after 2 cycles, ABVD x 2 + IFRT if < CR after 2 cycles | |||
| **Escalated BEACOPP if IPFP score 4–7 and age less than 60 years | |||
| Abbreviations: ABVD, doxorubicin, bleomycin, vinblastine and dacarbazine; CR, complete response; IFRT, involved field radiotherapy; min, minimum; max, maximum. | |||
| IA, IIA | Low | Not applicable | ABVD x 4 or ABVD x 2 + IFRT* |
| Any stage with B symptoms or III or IV | Low | 0–3 | ABVD until 2 cycles past CR (min 6, max 8) |
| Any stage with B symptoms or III or IV | Low | 4–7 | Intensified chemotherapy** |
| Any stage | High | 0–7 | Chemotherapy as above followed by IFRT to the bulky site |