Table 1. Modified Ann Arbor staging... | American Society of Hematology

Table 1.

Modified Ann Arbor staging system for Hodgkin lymphoma.

Stage Involvement
Single lymph node region (I) or one extralymphatic site (I_E). Two or more lymph node regions, same side of the diaphragm (II) or local extralymphatic extension plus one or more lymph node regions same side of the diaphragm (II_E). Lymph node regions on both sides of the diaphragm (III) which may be accompanied by local extralymphatic extension (III_E). Diffuse involvement of one or more extralymphatic organs or sites.

Stage Involvement

Single lymph node region (I) or one extralymphatic site (I_E).
Two or more lymph node regions, same side of the diaphragm (II) or local extralymphatic extension plus one or more lymph node regions same side of the diaphragm (II_E).
Lymph node regions on both sides of the diaphragm (III) which may be accompanied by local extralymphatic extension (III_E).
Diffuse involvement of one or more extralymphatic organs or sites.

Symptoms
Bulky tumor is defined as any single mass of tumor tissue exceeding 10 cm in largest diameter. The previously used definition of a mediastinal mass exceeding 1/3 of the maximum transverse transthoracic diameter measured on a standard posterior-anterior chest radiograph is obsolete in an era with widely available computed tomographic scans.
A = no B symptoms
B = presence of at least one of these: unexplained weight loss > 10 % baseline during 6 months prior to staging recurrent unexplained fever > 38° C recurrent night sweats

Symptoms
Bulky tumor is defined as any single mass of tumor tissue exceeding 10 cm in largest diameter. The previously used definition of a mediastinal mass exceeding 1/3 of the maximum transverse transthoracic diameter measured on a standard posterior-anterior chest radiograph is obsolete in an era with widely available computed tomographic scans.
A = no B symptoms
B = presence of at least one of these: unexplained weight loss > 10 % baseline during 6 months prior to staging recurrent unexplained fever > 38° C recurrent night sweats