Table 1. Drug-herb interactions. Herb .... | American Society of Hematology

Table 1.

Drug-herb interactions.

Herb	Drug	Effect
Table modified after reference 17
Echinacea	Cyclophosphamide  Vinca alkaloids	CYP3A4 induction
Essiac	Anthraquinones  Others	Inhibition of CYP3A causes synergism with chemotherapy
Garlic	Warfarin	Interaction, decreased effect
Ginkgo	Cyclophosphamide  Vinca alkaloids	CYP3A4 & CYP2C19 inhibition
Ginseng	Cyclophosphamide	CYP3A4 inhibition
Milk thistle	Doxorubicin	Inhibition of P450 thus decreasing metabolism of doxorubicin
St. John’s wort	Cyclosporin  Ironotecan  Taxanes  Imatinib	Subtherapeutic levels of chemotherapeutic agents metabolized by CYP3A4

Herb	Drug	Effect
Table modified after reference 17
Echinacea	Cyclophosphamide  Vinca alkaloids	CYP3A4 induction
Essiac	Anthraquinones  Others	Inhibition of CYP3A causes synergism with chemotherapy
Garlic	Warfarin	Interaction, decreased effect
Ginkgo	Cyclophosphamide  Vinca alkaloids	CYP3A4 & CYP2C19 inhibition
Ginseng	Cyclophosphamide	CYP3A4 inhibition
Milk thistle	Doxorubicin	Inhibition of P450 thus decreasing metabolism of doxorubicin
St. John’s wort	Cyclosporin  Ironotecan  Taxanes  Imatinib	Subtherapeutic levels of chemotherapeutic agents metabolized by CYP3A4