Molecular definition of small, distinct prognostic subgroups

Treatment efficacy predicted by genetic testing

Highly individualized therapy

Multi-component therapy composed of

• → cytotoxic/antimetabolic agents

• → several antibodies

• → radioimmunotherapy

• → gene therapy

• → new agents (pro-apoptotic drugs)

Adjuvant concepts to eradicate minimal residual disease (MRD)

Decreased use of autologous stem cell transplantation (SCT)

Median duration of remission after initial therapy > 6 years

Cure?