Summary of recent major randomized trials for advanced chronic lymphocytic leukemia (CLL) in treatment-naïve patients.
| . | Study . | n . | CR (%) . | PR (%) . | Response Duration (median, months) . | Survival (median, months) . |
|---|---|---|---|---|---|---|
| Please note that the response definitions varied considerably among the 4 trials. In the study by Leporrier et al.11 a systematic evaluation of the bone marrow was not performed routinely to confirm a CR; thus, the CR rates are somewhat higher than in the other trials. | ||||||
| Abbreviations: CAP, cyclophosphamide, doxorubicin, prednisone; CHOP, cyclophosphamide, doxorubicin, vincristine, prednisone; CR, complete response; PR, partial response; NR, not reached. | ||||||
| Rai9 | Fludarabine | 170 | 20 | 43 | 25 | 66 |
| Chlorambucil | 181 | 4 | 33 | 14 | 56 | |
| Johnson10 | Fludarabine | 52 | 23 | 48 | NR | 60% at 4 years |
| CAP | 48 | 17 | 43 | 6.9 | 60% at 4 years | |
| Leporrier11 | Fludarabine | 341 | 40.1 | 31 | 31.7 | 69 |
| CAP | 240 | 15.2 | 43 | 27.7 | 70 | |
| CHOP | 305 | 29.6 | 41.9 | 29.5 | 67 | |
| Robak37 | Cladribine + prednisone | 126 | 47 | 40 | 21 | 78% at 2 years |
| Chlorambucil + prednisone | 103 | 12 | 45 | 18 | 82% at 2 years | |
| Eichhorst17 | Fludarabine | 182 | 4.9 | 78 | 20 | Median not reached |
| Fludarabine, cyclophosphamide | 180 | 16.5 | 78 | 48 | Median not reached | |
| . | Study . | n . | CR (%) . | PR (%) . | Response Duration (median, months) . | Survival (median, months) . |
|---|---|---|---|---|---|---|
| Please note that the response definitions varied considerably among the 4 trials. In the study by Leporrier et al.11 a systematic evaluation of the bone marrow was not performed routinely to confirm a CR; thus, the CR rates are somewhat higher than in the other trials. | ||||||
| Abbreviations: CAP, cyclophosphamide, doxorubicin, prednisone; CHOP, cyclophosphamide, doxorubicin, vincristine, prednisone; CR, complete response; PR, partial response; NR, not reached. | ||||||
| Rai9 | Fludarabine | 170 | 20 | 43 | 25 | 66 |
| Chlorambucil | 181 | 4 | 33 | 14 | 56 | |
| Johnson10 | Fludarabine | 52 | 23 | 48 | NR | 60% at 4 years |
| CAP | 48 | 17 | 43 | 6.9 | 60% at 4 years | |
| Leporrier11 | Fludarabine | 341 | 40.1 | 31 | 31.7 | 69 |
| CAP | 240 | 15.2 | 43 | 27.7 | 70 | |
| CHOP | 305 | 29.6 | 41.9 | 29.5 | 67 | |
| Robak37 | Cladribine + prednisone | 126 | 47 | 40 | 21 | 78% at 2 years |
| Chlorambucil + prednisone | 103 | 12 | 45 | 18 | 82% at 2 years | |
| Eichhorst17 | Fludarabine | 182 | 4.9 | 78 | 20 | Median not reached |
| Fludarabine, cyclophosphamide | 180 | 16.5 | 78 | 48 | Median not reached | |