Parameters predicting the prognosis of chronic lymphocytic leukemia (CLL) independent of the disease stage.
| Parameter . | Reference . |
|---|---|
| Aberrations in chromosomes 13 (13q–), 11 (11q–) and 17 (17p–) | 3 |
| Cytoplasmic ZAP70 in CLL cells | 4,5 |
| Expression of CD38 on CLL cells | 6,7 |
| Lymphocyte doubling time | 8 |
| Serum β2-microglobulin concentration | 9 |
| Serum levels of soluble CD23 | 10,11 |
| Serum thymidine kinase activity | 12 |
| Somatic hyper-mutations of the immunoglobulin VH-gene region | 6,13 |
| Parameter . | Reference . |
|---|---|
| Aberrations in chromosomes 13 (13q–), 11 (11q–) and 17 (17p–) | 3 |
| Cytoplasmic ZAP70 in CLL cells | 4,5 |
| Expression of CD38 on CLL cells | 6,7 |
| Lymphocyte doubling time | 8 |
| Serum β2-microglobulin concentration | 9 |
| Serum levels of soluble CD23 | 10,11 |
| Serum thymidine kinase activity | 12 |
| Somatic hyper-mutations of the immunoglobulin VH-gene region | 6,13 |