Table 2 Effects of treatment with low... | American Society of Hematology

Table 2

Effects of treatment with low doses of RG7112 and Peg-IFNα 2a alone or in combination on the number of WT JAK2 hematopoietic colonies

Patient number*	JAK2 V617F allele burden (%)	Total of colonies genotyped	% Of hematopoietic colonies with WT JAK2
Patient number*	JAK2 V617F allele burden (%)	Total of colonies genotyped	Cytokines only (control)	Peg-IFNα 2a	RG7112	RG7112 + IFNα
2	14	127	58	56.5	46	70.6†
15	70	129	14.3	26.1	23	40*
5	49	144	70	67	71	79
6	22	132	38	47	45	50
13	75	180	21	32	25	50†
14	20	168	31	44	28	45
3	40	189	79	83	79	87
16	50	121	4	6	6	24†
22	70	121	6	0	0	27†
21	45	112	50	80	58.3	83.3
19	+	105	12.5	20	64	90.9†

Patient number*	JAK2 V617F allele burden (%)	Total of colonies genotyped	% Of hematopoietic colonies with WT JAK2
Patient number*	JAK2 V617F allele burden (%)	Total of colonies genotyped	Cytokines only (control)	Peg-IFNα 2a	RG7112	RG7112 + IFNα
2	14	127	58	56.5	46	70.6†
15	70	129	14.3	26.1	23	40*
5	49	144	70	67	71	79
6	22	132	38	47	45	50
13	75	180	21	32	25	50†
14	20	168	31	44	28	45
3	40	189	79	83	79	87
16	50	121	4	6	6	24†
22	70	121	6	0	0	27†
21	45	112	50	80	58.3	83.3
19	+	105	12.5	20	64	90.9†

24 to 48 colonies were plucked and examined in each condition.

Patient numbers are listed in supplemental Table 2.

†

Benefits of the combination therapy are defined as the appearance of at least a 10% greater increase in WT colonies after combination therapy compared with the colonies treated with a single agent.

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