Results of the stepwise Cox proportional hazards analysis for 922 β-thalassemia patients in cohort C
| Ameliorating alleles . | P . | HR . | 95% CI . |
|---|---|---|---|
| KLF1 mutations | <.001 | 0.213 | 0.119-0.379 |
| HBB mutations (β+) | <.001 | 0.353 | 0.305-0.409 |
| HGB2 | <.001 | 0.512 | 0.432-0.608 |
| rs7482114 (XmnI, +) | |||
| HBA mutations | <.001 | 0.671 | 0.600-0.750 |
| HBS1L-MYB intergenic region | <.001 | 0.724 | 0.644-0.813 |
| rs9399137 (C) | |||
| BCL11A | <.001 | 0.761 | 0.680-0.851 |
| rs766432 (T) |
| Ameliorating alleles . | P . | HR . | 95% CI . |
|---|---|---|---|
| KLF1 mutations | <.001 | 0.213 | 0.119-0.379 |
| HBB mutations (β+) | <.001 | 0.353 | 0.305-0.409 |
| HGB2 | <.001 | 0.512 | 0.432-0.608 |
| rs7482114 (XmnI, +) | |||
| HBA mutations | <.001 | 0.671 | 0.600-0.750 |
| HBS1L-MYB intergenic region | <.001 | 0.724 | 0.644-0.813 |
| rs9399137 (C) | |||
| BCL11A | <.001 | 0.761 | 0.680-0.851 |
| rs766432 (T) |
Gender (HR = 0.893, P = .107) and rs11886868 in BCL11A (HR = 0.871, P = .415) were removed from the model. The discriminative ability of the model was high (Harrell’s concordance index = 0.714, R2 = 0.344).