Table 5 Relative transcript levels of... | American Society of Hematology

Table 5

Relative transcript levels of early, intermediate, and mature gametocyte stage markers in bone marrow positive for the different gametocyte stages according to demographic and clinical parameters

		Relative transcript levels (×100)*
		Early			Intermediate			Mature
	n	GM (95%CI)	P	n	GM (95%CI)	P	n	GM (95%CI)	P
Age (months)
≤20	76	17.2 (12.0, 24.9)	.296	61	40.8 (23.2, 72.0)	.314	35	8.5 (3.2, 22.7)	.200
>20	53	12.8 (8.2, 19.8)	.296	48	26.3 (13.4, 51.4)	.314	35	20.3 (7.8, 52.6)	.200
Sex
Male	73	14.9 (10.2, 21.9)	.871	61	29.9 (16.7, 53.3)	.541	39	13.6 (5.7, 32.4)	.90
Female	56	15.7 (10.3, 23.7)	.871	48	39.1 (20.2, 75.5)	.541	31	12.5 (4.1, 38.5)	.90
Fever
No	52	21.0 (13.6, 32.4)	.061	42	48.0 (25.7, 89.4)	.195	26	40.6 (13.2, 125.1)	.009
Yes	77	12.3 (8.5, 17.7)	.061	67	26.9 (15.0, 48.3)	.195	44	6.7 (3.0, 15.1)	.009
CRP†
Low	64	14.1 (9.2, 21.6)	.880	51	31.3 (15.9, 61.5)	.790	26	4.5 (1.5, 13.3)	.016
High	61	14.7 (10.2, 21.3)	.880	55	35.2 (19.6, 63.5)	.790	41	23.5 (10.1, 54.7)	.016
Severe anemia
No	71	16.2 (11.2, 23.4)	.639	59	31.8 (16.8, 60.1)	.776	24	2.7 (0.9, 7.9)	<.001
Yes	58	14.2 (9.2, 21.9)	.639	50	36.0 (20.2, 64.2)	.776	46	30.1 (13.8, 65.4)	<.001
EPO‡
Low	70	14.3 (9.9, 20.6)	.898	60	26.1 (14.2, 47.9)	.236	31	3.8 (1.4, 10.2)	.002
High	56	14.8 (9.6, 23.0)	.898	47	44.2 (23.5, 83.1)	.236	37	30.1 (12.8, 70.8)	.002
Asexual parasitemia (BM)¶
Submic	76	21.9 (15.9, 30.2)	.001	62	60.1 (37.9, 95.4)	<.001	29	9.7 (3.2, 29.3)	.386
Patent	44	8.4 (5.0, 14.1)	.001	40	10.7 (4.9, 23.3)	<.001	35	17.6 (7.3, 42.5)	.386
Hemozoin
No	52	24.0 (16.5, 34.8)	.009	43	60.0 (35.7, 100.9)	.006	16	8.6 (2.0, 37.8)	.317
Yes	45	10.6 (6.4, 17.5)	.009	39	17.1 (8.0, 36.3)	.006	33	20.9 (7.4, 59.3)	.317
Dyserythropoiesis
No	30	18.9 (11.9, 29.9)	.479	25	27.5 (11.6, 65.5)	.753	7	13.4 (0.5, 376.1)	.885
Yes	70	14.8 (9.9, 22.1)	.479	61	32.5 (18.3, 57.7)	.753	45	11.3 (4.9, 25.9)	.885

		Relative transcript levels (×100)*
		Early			Intermediate			Mature
	n	GM (95%CI)	P	n	GM (95%CI)	P	n	GM (95%CI)	P
Age (months)
≤20	76	17.2 (12.0, 24.9)	.296	61	40.8 (23.2, 72.0)	.314	35	8.5 (3.2, 22.7)	.200
>20	53	12.8 (8.2, 19.8)	.296	48	26.3 (13.4, 51.4)	.314	35	20.3 (7.8, 52.6)	.200
Sex
Male	73	14.9 (10.2, 21.9)	.871	61	29.9 (16.7, 53.3)	.541	39	13.6 (5.7, 32.4)	.90
Female	56	15.7 (10.3, 23.7)	.871	48	39.1 (20.2, 75.5)	.541	31	12.5 (4.1, 38.5)	.90
Fever
No	52	21.0 (13.6, 32.4)	.061	42	48.0 (25.7, 89.4)	.195	26	40.6 (13.2, 125.1)	.009
Yes	77	12.3 (8.5, 17.7)	.061	67	26.9 (15.0, 48.3)	.195	44	6.7 (3.0, 15.1)	.009
CRP†
Low	64	14.1 (9.2, 21.6)	.880	51	31.3 (15.9, 61.5)	.790	26	4.5 (1.5, 13.3)	.016
High	61	14.7 (10.2, 21.3)	.880	55	35.2 (19.6, 63.5)	.790	41	23.5 (10.1, 54.7)	.016
Severe anemia
No	71	16.2 (11.2, 23.4)	.639	59	31.8 (16.8, 60.1)	.776	24	2.7 (0.9, 7.9)	<.001
Yes	58	14.2 (9.2, 21.9)	.639	50	36.0 (20.2, 64.2)	.776	46	30.1 (13.8, 65.4)	<.001
EPO‡
Low	70	14.3 (9.9, 20.6)	.898	60	26.1 (14.2, 47.9)	.236	31	3.8 (1.4, 10.2)	.002
High	56	14.8 (9.6, 23.0)	.898	47	44.2 (23.5, 83.1)	.236	37	30.1 (12.8, 70.8)	.002
Asexual parasitemia (BM)¶
Submic	76	21.9 (15.9, 30.2)	.001	62	60.1 (37.9, 95.4)	<.001	29	9.7 (3.2, 29.3)	.386
Patent	44	8.4 (5.0, 14.1)	.001	40	10.7 (4.9, 23.3)	<.001	35	17.6 (7.3, 42.5)	.386
Hemozoin
No	52	24.0 (16.5, 34.8)	.009	43	60.0 (35.7, 100.9)	.006	16	8.6 (2.0, 37.8)	.317
Yes	45	10.6 (6.4, 17.5)	.009	39	17.1 (8.0, 36.3)	.006	33	20.9 (7.4, 59.3)	.317
Dyserythropoiesis
No	30	18.9 (11.9, 29.9)	.479	25	27.5 (11.6, 65.5)	.753	7	13.4 (0.5, 376.1)	.885
Yes	70	14.8 (9.9, 22.1)	.479	61	32.5 (18.3, 57.7)	.753	45	11.3 (4.9, 25.9)	.885

P values are from Student t test using log transformed values.

CI, confidence interval; GM, geometric mean; submic, submicroscopic infections.

Ratio (×100) between copy numbers of gametocyte transcripts and P falciparum ubiquitin-conjugating enzyme transcript.

†

Median: 7.44 mg/dL.

‡

Median: 88.65 U/L.

Submicroscopic if parasites were detected only by qPCR.

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