Retrovirus integration sites of leukemic cells
| Transduced gene . | Mouse ID . | Nearest gene . | Chromosome no. . | Distance to gene (start or end) . | Location . | Forward or reverse orientation . | RTCGD hits . |
|---|---|---|---|---|---|---|---|
| Evi1 | 1 | Bcas1 | 2 | 14965 bp | 5′ | R | 2 |
| Evi1* | 2 | C/EBPβ | 2 | 75063 bp | 3′ | F | 25 |
| Evi1 | 3 | C/EBPβ | 2 | 62583 bp | 3′ | F | 25 |
| Evi1 | 4 | C/EBPβ | 2 | 86723 bp | 3′ | F | 25 |
| Evi1 | 5 | Pnp2 | 14 | 11834 bp | 3′ | R | 0 |
| Evi1 | 5 | Rps6ka1 | 4 | 32680 bp | 3′ | R | 4 |
| Evi1 | 5 | Rapgef4 | 2 | — | Intron 6 | R | 0 |
| Evi1 | 6 | C/EBPβ | 2 | 74775 bp | 3′ | F | 25 |
| Evi1 | 7 | C/EBPβ | 2 | 74873 bp | 3′ | F | 25 |
| Evi1 | 7 | E2F2 | 4 | — | Intron 1 | F | 10 |
| Evi1 | 8 | C/EBPβ | 2 | 81088 bp | 3′ | F | 25 |
| Evi1* | 15 | Atp10a | 7 | 2629 bp | 3′ | R | 0 |
| Evi1 | 21 | TLR7 | X | — | Intron 2 | R | 0 |
| Evi1+LAP | 606 | eIF4E3 | 6 | 290630 bp | 3′ | F | 1 |
| Evi1+LAP* | 504 | Ivns1abp | 1 | 64767 bp | 5′ | R | 2 |
| Evi1+LIP+LAP* | 302 | LOC70873 | 2 | — | Intron 9 | R | 0 |
| Evi1+LIP+LAP* | 302 | Prdx3 | 19 | — | Intron 1 | F | 0 |
| LIP | 407 | Ly86 | 13 | 66277 bp | 3′ | F | 2 |
| LIP | 408 | Epb4.1 | 4 | 68817 bp | 5′ | R | 0 |
| Transduced gene . | Mouse ID . | Nearest gene . | Chromosome no. . | Distance to gene (start or end) . | Location . | Forward or reverse orientation . | RTCGD hits . |
|---|---|---|---|---|---|---|---|
| Evi1 | 1 | Bcas1 | 2 | 14965 bp | 5′ | R | 2 |
| Evi1* | 2 | C/EBPβ | 2 | 75063 bp | 3′ | F | 25 |
| Evi1 | 3 | C/EBPβ | 2 | 62583 bp | 3′ | F | 25 |
| Evi1 | 4 | C/EBPβ | 2 | 86723 bp | 3′ | F | 25 |
| Evi1 | 5 | Pnp2 | 14 | 11834 bp | 3′ | R | 0 |
| Evi1 | 5 | Rps6ka1 | 4 | 32680 bp | 3′ | R | 4 |
| Evi1 | 5 | Rapgef4 | 2 | — | Intron 6 | R | 0 |
| Evi1 | 6 | C/EBPβ | 2 | 74775 bp | 3′ | F | 25 |
| Evi1 | 7 | C/EBPβ | 2 | 74873 bp | 3′ | F | 25 |
| Evi1 | 7 | E2F2 | 4 | — | Intron 1 | F | 10 |
| Evi1 | 8 | C/EBPβ | 2 | 81088 bp | 3′ | F | 25 |
| Evi1* | 15 | Atp10a | 7 | 2629 bp | 3′ | R | 0 |
| Evi1 | 21 | TLR7 | X | — | Intron 2 | R | 0 |
| Evi1+LAP | 606 | eIF4E3 | 6 | 290630 bp | 3′ | F | 1 |
| Evi1+LAP* | 504 | Ivns1abp | 1 | 64767 bp | 5′ | R | 2 |
| Evi1+LIP+LAP* | 302 | LOC70873 | 2 | — | Intron 9 | R | 0 |
| Evi1+LIP+LAP* | 302 | Prdx3 | 19 | — | Intron 1 | F | 0 |
| LIP | 407 | Ly86 | 13 | 66277 bp | 3′ | F | 2 |
| LIP | 408 | Epb4.1 | 4 | 68817 bp | 5′ | R | 0 |
bp, base pair.
The same integration sites are identified in the second leukemic cells as in the first ones.