T-cell genes differentially induced by MLN-derived dendritic cells
| Fold change . | Gene title . | Gene symbol . | Genebank40 . |
|---|---|---|---|
| Up-regulated | |||
| 4.14 | Stimulated by retinoic acid gene 6 | Stra6 | NM_009291.1 |
| 2.37 | Leucine zipper transcription factor-like 1 | Lztfl1 | NM_033322.1 |
| 2.00 | Hypermethylated in cancer 1 | Hic1 | NM_010430.1 |
| 1.73 | Xanthine dehydrogenase | Xdh | AV286265 |
| 1.63 | Granzyme G | Gzmg | NM_010375.1 |
| 1.63 | Purinergic receptor P2X, ligand-gated ion channel 4 | P2rx4 | AJ251462.1 |
| 1.49 | Serine (or cysteine) proteinase inhibitor, clade E, member 2 | Serpine2 | NM_009255.1 |
| 1.49 | Serine (or cysteine) proteinase inhibitor, clade A, member 3G | Serpina3g | BC002065.1 |
| 1.45 | Growth factor independent 1 | Gfi1 | NM_010278.1 |
| 1.45 | Glucosaminyl (N-acetyl) transferase 2, I-branching enzyme | Gcnt2 | BM236768 |
| 1.44 | Transglutaminase 2, C polypeptide* (n=2) | Tgm2 | BB550124 |
| 1.42 | Tribbles homolog 2 (Drosophila) | Trib2 | BC027159.1 |
| 1.38 | Leukocyte immunoglobulin-like receptor, subfamily B, member 4 | Lilrb4 | U05264.1 |
| 1.35 | Sprouty-related, EVH1 domain containing 2 | Spred2 | AV229054 |
| 1.35 | GTPase, IMAP family member 3 | Gimap3 | NM_031247.1 |
| Down-regulated | |||
| −1.26 | CD44 antigen | Cd44 | BC005676.1 |
| −1.26 | Interleukin 7 receptor | Il7r | NM_008372.2 |
| −1.31 | Asparagine synthetase* (n=2) | Asns | BC005552.1 |
| −1.32 | ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 | St8sia4 | NM_009183.1 |
| −1.39 | Beta galactoside alpha 2,6 sialyltransferase 1 | St6gal1 | BG075800 |
| −1.42 | Inducible T-cell co-stimulator* (n=2) | Icos | NM_017480.1 |
| −1.42 | Membrane-spanning 4-domains, subfamily A, member 4C | Ms4a4c | NM_022429.1 |
| −1.45 | Selectin, lymphocyte* (n=2) | Sell | M36005.1 |
| −1.49 | Prion protein* (n=2) | Prnp | NM_011170.1 |
| −1.50 | RIKEN cDNA 1190002H23 gene* (n=2) | 1190002H23Rik | BB408123 |
| −1.56 | Syndecan binding protein (syntenin) 2 | Sdcbp2 | BC005556.1 |
| −1.61 | Glutamic pyruvate transaminase (alanine aminotransferase) 2 | Gpt2 | BI648645 |
| −1.63 | Interleukin 10 | Il10 | NM_010548.1 |
| −1.64 | Palmitoyl-protein thioesterase precursor | ppt | AF087568.1 |
| −1.69 | Cystathionase (cystathionine gamma-lyase) | Cth | BC019483.1 |
| −1.81 | Interleukin 18 receptor 1 | Il18r1 | NM_008365.1 |
| −1.95 | Plexin C1* (n=2) | Plxnc1 | BB765457 |
| −2.02 | Interleukin 24 | Il24 | AF333251.1 |
| −2.11 | Hemogen | Hemgn | NM_053149.1 |
| −2.23 | Killer cell lectin-like receptor subfamily C, member 1 /// member 2 | Klrc1 /// Klrc2 | AF106008.1 |
| −2.25 | Semaphorin 4A* (n=2) | Sema4a | NM_013658.1 |
| −4.23 | Lamin A | Lmna | NM_019390.1 |
| Fold change . | Gene title . | Gene symbol . | Genebank40 . |
|---|---|---|---|
| Up-regulated | |||
| 4.14 | Stimulated by retinoic acid gene 6 | Stra6 | NM_009291.1 |
| 2.37 | Leucine zipper transcription factor-like 1 | Lztfl1 | NM_033322.1 |
| 2.00 | Hypermethylated in cancer 1 | Hic1 | NM_010430.1 |
| 1.73 | Xanthine dehydrogenase | Xdh | AV286265 |
| 1.63 | Granzyme G | Gzmg | NM_010375.1 |
| 1.63 | Purinergic receptor P2X, ligand-gated ion channel 4 | P2rx4 | AJ251462.1 |
| 1.49 | Serine (or cysteine) proteinase inhibitor, clade E, member 2 | Serpine2 | NM_009255.1 |
| 1.49 | Serine (or cysteine) proteinase inhibitor, clade A, member 3G | Serpina3g | BC002065.1 |
| 1.45 | Growth factor independent 1 | Gfi1 | NM_010278.1 |
| 1.45 | Glucosaminyl (N-acetyl) transferase 2, I-branching enzyme | Gcnt2 | BM236768 |
| 1.44 | Transglutaminase 2, C polypeptide* (n=2) | Tgm2 | BB550124 |
| 1.42 | Tribbles homolog 2 (Drosophila) | Trib2 | BC027159.1 |
| 1.38 | Leukocyte immunoglobulin-like receptor, subfamily B, member 4 | Lilrb4 | U05264.1 |
| 1.35 | Sprouty-related, EVH1 domain containing 2 | Spred2 | AV229054 |
| 1.35 | GTPase, IMAP family member 3 | Gimap3 | NM_031247.1 |
| Down-regulated | |||
| −1.26 | CD44 antigen | Cd44 | BC005676.1 |
| −1.26 | Interleukin 7 receptor | Il7r | NM_008372.2 |
| −1.31 | Asparagine synthetase* (n=2) | Asns | BC005552.1 |
| −1.32 | ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 | St8sia4 | NM_009183.1 |
| −1.39 | Beta galactoside alpha 2,6 sialyltransferase 1 | St6gal1 | BG075800 |
| −1.42 | Inducible T-cell co-stimulator* (n=2) | Icos | NM_017480.1 |
| −1.42 | Membrane-spanning 4-domains, subfamily A, member 4C | Ms4a4c | NM_022429.1 |
| −1.45 | Selectin, lymphocyte* (n=2) | Sell | M36005.1 |
| −1.49 | Prion protein* (n=2) | Prnp | NM_011170.1 |
| −1.50 | RIKEN cDNA 1190002H23 gene* (n=2) | 1190002H23Rik | BB408123 |
| −1.56 | Syndecan binding protein (syntenin) 2 | Sdcbp2 | BC005556.1 |
| −1.61 | Glutamic pyruvate transaminase (alanine aminotransferase) 2 | Gpt2 | BI648645 |
| −1.63 | Interleukin 10 | Il10 | NM_010548.1 |
| −1.64 | Palmitoyl-protein thioesterase precursor | ppt | AF087568.1 |
| −1.69 | Cystathionase (cystathionine gamma-lyase) | Cth | BC019483.1 |
| −1.81 | Interleukin 18 receptor 1 | Il18r1 | NM_008365.1 |
| −1.95 | Plexin C1* (n=2) | Plxnc1 | BB765457 |
| −2.02 | Interleukin 24 | Il24 | AF333251.1 |
| −2.11 | Hemogen | Hemgn | NM_053149.1 |
| −2.23 | Killer cell lectin-like receptor subfamily C, member 1 /// member 2 | Klrc1 /// Klrc2 | AF106008.1 |
| −2.25 | Semaphorin 4A* (n=2) | Sema4a | NM_013658.1 |
| −4.23 | Lamin A | Lmna | NM_019390.1 |
Naive donor-type allogeneic T cells were cocultured for 4 days with MLN-derived host-type dendritic cells, total RNA was extracted, and microarray analysis was performed using the GeneChip Mouse Genome 430A 2.0 Array (Affymetrix). Gene expression levels were compared with T cells cultured with PLN-derived dendritic cells. Greater than 1.25-fold changes with P < .001 were chosen.