T-cell genes differentially induced by liver-derived dendritic cells
| Fold change . | Gene title . | Gene symbol . | Genebank40 . |
|---|---|---|---|
| Up-regulated | |||
| 2,10 | Regulator of G-protein signaling 16 | Rgs16 | U94828.1 |
| 2,09 | Granzyme G | Gzmg | NM_010375.1 |
| 1,92 | Secreted phosphoprotein 1 | Spp1 | NM_009263.1 |
| 1,89 | Granzyme E* (n=2) | Gzme | NM_010373.1 |
| 1,77 | Chemokine (C-X-C motif) receptor 6 | Cxcr6 | AF301018.1 |
| 1,64 | S100 calcium binding protein A4 | S100a4 | D00208.1 |
| 1,49 | Granzyme C | Gzmc | NM_010371.1 |
| 1,36 | Thioredoxin interacting protein | Txnip | NM_023719.1 |
| 1,32 | S100 calcium binding protein A10 (calpactin) | S100a10 | NM_009112.1 |
| 1,32 | Poly A binding protein, cytoplasmic 1 | Pabpc1 | NM_008774.1 |
| 1,29 | Semaphorin 4A | Sema4a | NM_013658.1 |
| 1,29 | Ribosomal protein S2* (n=2) | Rps2 | AK004568.1 |
| 1,26 | Similar to glyceraldehyde-3-phosphate dehydrogenase | LOC14433 | NM_008084.1 |
| 1,26 | Rho, GDP dissociation inhibitor (GDI) beta | Arhgdib | AK002516.1 |
| 1,26 | Ribosomal protein, large, P1 | Rplp1 | NM_018853.1 |
| 1,26 | Lectin, galactose binding, soluble 1 | Lgals1 | NM_008495.1 |
| 1,26 | Ribosomal protein L5 | Rpl5 | BC026934.1 |
| 1,26 | Ribosomal protein L26 | Rpl26 | NM_009080.1 |
| 1,26 | Ribosomal protein L13 | Rpl13 | NM_016738.1 |
| 1,26 | Actin, beta, cytoplasmic* (n=2) | Actb | M12481.1 |
| 1,26 | Adenylosuccinate lyase | Adsl | K00131.1 |
| 1,26 | Caspase 3, apoptosis related cysteine protease | Casp3 | D86352.1 |
| Down-regulated | |||
| −1,45 | Calponin 3, acidic* (n=3) | Cnn3 | BB724741 |
| −1,49 | Suppressor of cytokine signaling 3* (n=2) | Socs3 | BB241535 |
| −1,49 | RIKEN cDNA 1110035L05 gene | 1110035L05Rik | NM_026125.1 |
| −1,52 | Calponin 3, acidic | Cnn3 | AV172168 |
| −1,55 | Tumor necrosis factor receptor superfamily, member 8 | Tnfrsf8 | NM_009401.1 |
| −1,59 | Interleukin 1 receptor, type II | Il1r2 | NM_010555.1 |
| −1,70 | T-cell receptor gamma chain /// T cell receptor gamma chain | Tcrg | NM_011558.2 |
| −1,74 | Histocompatibility 2, Q region locus 10 | H2-Q10 | BC011215.1 |
| −1,76 | T cell receptor associated transmembrane adaptor 1 | Trat1 | BB622792 |
| −1,78 | FERM domain containing 4B | Frmd4b | BB009122 |
| −1,95 | Aryl-hydrocarbon receptor | Ahr | NM_013464.1 |
| −2,00 | Insulin-like growth factor binding protein 4* (n=4) | Igfbp4 | BC019836.1 |
| −2,45 | Extracellular matrix protein 1 | Ecm1 | NM_007899.1 |
| −3,32 | Lumican | Lum | AK014312.1 |
| −3,35 | Interleukin 17 | Il17 | NM_010552.1 |
| −4,61 | Transglutaminase 2, C polypeptide* (n=4) | Tgm2 | BC016492.1 |
| Fold change . | Gene title . | Gene symbol . | Genebank40 . |
|---|---|---|---|
| Up-regulated | |||
| 2,10 | Regulator of G-protein signaling 16 | Rgs16 | U94828.1 |
| 2,09 | Granzyme G | Gzmg | NM_010375.1 |
| 1,92 | Secreted phosphoprotein 1 | Spp1 | NM_009263.1 |
| 1,89 | Granzyme E* (n=2) | Gzme | NM_010373.1 |
| 1,77 | Chemokine (C-X-C motif) receptor 6 | Cxcr6 | AF301018.1 |
| 1,64 | S100 calcium binding protein A4 | S100a4 | D00208.1 |
| 1,49 | Granzyme C | Gzmc | NM_010371.1 |
| 1,36 | Thioredoxin interacting protein | Txnip | NM_023719.1 |
| 1,32 | S100 calcium binding protein A10 (calpactin) | S100a10 | NM_009112.1 |
| 1,32 | Poly A binding protein, cytoplasmic 1 | Pabpc1 | NM_008774.1 |
| 1,29 | Semaphorin 4A | Sema4a | NM_013658.1 |
| 1,29 | Ribosomal protein S2* (n=2) | Rps2 | AK004568.1 |
| 1,26 | Similar to glyceraldehyde-3-phosphate dehydrogenase | LOC14433 | NM_008084.1 |
| 1,26 | Rho, GDP dissociation inhibitor (GDI) beta | Arhgdib | AK002516.1 |
| 1,26 | Ribosomal protein, large, P1 | Rplp1 | NM_018853.1 |
| 1,26 | Lectin, galactose binding, soluble 1 | Lgals1 | NM_008495.1 |
| 1,26 | Ribosomal protein L5 | Rpl5 | BC026934.1 |
| 1,26 | Ribosomal protein L26 | Rpl26 | NM_009080.1 |
| 1,26 | Ribosomal protein L13 | Rpl13 | NM_016738.1 |
| 1,26 | Actin, beta, cytoplasmic* (n=2) | Actb | M12481.1 |
| 1,26 | Adenylosuccinate lyase | Adsl | K00131.1 |
| 1,26 | Caspase 3, apoptosis related cysteine protease | Casp3 | D86352.1 |
| Down-regulated | |||
| −1,45 | Calponin 3, acidic* (n=3) | Cnn3 | BB724741 |
| −1,49 | Suppressor of cytokine signaling 3* (n=2) | Socs3 | BB241535 |
| −1,49 | RIKEN cDNA 1110035L05 gene | 1110035L05Rik | NM_026125.1 |
| −1,52 | Calponin 3, acidic | Cnn3 | AV172168 |
| −1,55 | Tumor necrosis factor receptor superfamily, member 8 | Tnfrsf8 | NM_009401.1 |
| −1,59 | Interleukin 1 receptor, type II | Il1r2 | NM_010555.1 |
| −1,70 | T-cell receptor gamma chain /// T cell receptor gamma chain | Tcrg | NM_011558.2 |
| −1,74 | Histocompatibility 2, Q region locus 10 | H2-Q10 | BC011215.1 |
| −1,76 | T cell receptor associated transmembrane adaptor 1 | Trat1 | BB622792 |
| −1,78 | FERM domain containing 4B | Frmd4b | BB009122 |
| −1,95 | Aryl-hydrocarbon receptor | Ahr | NM_013464.1 |
| −2,00 | Insulin-like growth factor binding protein 4* (n=4) | Igfbp4 | BC019836.1 |
| −2,45 | Extracellular matrix protein 1 | Ecm1 | NM_007899.1 |
| −3,32 | Lumican | Lum | AK014312.1 |
| −3,35 | Interleukin 17 | Il17 | NM_010552.1 |
| −4,61 | Transglutaminase 2, C polypeptide* (n=4) | Tgm2 | BC016492.1 |
Naive donor-type allogeneic T cells were cocultured for 4 days with liver-derived host-type dendritic cells, total RNA was extracted, and microarray analysis was performed using the GeneChip Mouse Genome 430A 2.0 Array (Affymetrix). Gene expression levels were compared with T cells cultured with spleen-derived dendritic cells. Greater than 1.25-fold changes with P<.001 were chosen.