Table 1 Effects of increasing Wnt... | American Society of Hematology

Table 1

Effects of increasing Wnt signaling in the myeloma bone microenvironment on trabecular structure

	Nontumor	5TGM1-pcDNA	5TGM1-pcDNA + LiCl	5TGM1−Δ NTCF4	5TGM1−Δ NTCF4 + LiCl
BV/TV, %	5.38 ± 0.26	2.83 ± 0.20*	4.60 ± 0.31†	3.75 ± 0.54*	5.42 ± 0.45†
Tb. no., 1/mm	2.81 ± 0.07	2.34 ± 0.07‡	2.70 ± 0.13†	2.65 ± 0.21	2.93 ± 0.09
Tb. thickness, mm	0.048 ± 0.001	0.045 ± 0.001*	0.048 ± 0.001†	0.043 ± 0.002*	0.047 ± 0.001
Tb. separation, mm	0.36 ± 0.01	0.43 ± 0.01*	0.38 ± 0.02†	0.39 ± 0.03	0.35 ± 0.01

	Nontumor	5TGM1-pcDNA	5TGM1-pcDNA + LiCl	5TGM1−Δ NTCF4	5TGM1−Δ NTCF4 + LiCl
BV/TV, %	5.38 ± 0.26	2.83 ± 0.20*	4.60 ± 0.31†	3.75 ± 0.54*	5.42 ± 0.45†
Tb. no., 1/mm	2.81 ± 0.07	2.34 ± 0.07‡	2.70 ± 0.13†	2.65 ± 0.21	2.93 ± 0.09
Tb. thickness, mm	0.048 ± 0.001	0.045 ± 0.001*	0.048 ± 0.001†	0.043 ± 0.002*	0.047 ± 0.001
Tb. separation, mm	0.36 ± 0.01	0.43 ± 0.01*	0.38 ± 0.02†	0.39 ± 0.03	0.35 ± 0.01

Trabecular bone volume (BV/TV), number, thickness and separation were calculated by microCT analysis of tibiae.

Tb indicates trabecular.

P < .05 compared with nontumor.

P < .05 compared with vehicle control.

P <.01 compared with nontumor.