Table 3 Significant association between... | American Society of Hematology

Table 3

Significant association between JAK2 intragene haplotypes and PV

Covariates/haplotypes	Significant individual haplotypes			Global P†
Covariates/haplotypes	Haplotype frequency	Odds ratios*	P	Global P†
Age at diagnosis, sex				<.001
AAAACTCAAGGGT	0.015	2000.2	.003	—
AAATCTTCTCGGT	0.148	0.528	.005	—
AACACTCAAGGGT‡	0.192	1.608	.026	—
GAAACTTCTCAGG	0.014	—	.038	—
GACACTCAAGGGT	0.178	1.765	.023	—
GGAAACCCTCAAG‡	0.130	0.556	.019	—
Age at diagnosis, sex, JAK2 mutation status				.034
AACACTCAAGGGT‡	0.192	1.20	.017	—
GGAAACCCTCAAG‡	0.130	0.36	.027	—

Covariates/haplotypes	Significant individual haplotypes			Global P†
Covariates/haplotypes	Haplotype frequency	Odds ratios*	P	Global P†
Age at diagnosis, sex				<.001
AAAACTCAAGGGT	0.015	2000.2	.003	—
AAATCTTCTCGGT	0.148	0.528	.005	—
AACACTCAAGGGT‡	0.192	1.608	.026	—
GAAACTTCTCAGG	0.014	—	.038	—
GACACTCAAGGGT	0.178	1.765	.023	—
GGAAACCCTCAAG‡	0.130	0.556	.019	—
Age at diagnosis, sex, JAK2 mutation status				.034
AACACTCAAGGGT‡	0.192	1.20	.017	—
GGAAACCCTCAAG‡	0.130	0.36	.027	—

PV indicates polycythemia vera; JAK2, Janus kinase 2; and —, not applicable.

Odds ratios computed for haplotypes with observed counts greater than 5.

Simulation based P values.

JAK2 intragene haplotypes that are significantly associated with PV, even after adjusting for JAK2V617F status.