Table 1 Drugs and dosing of alternating... | American Society of Hematology

Table 1

Drugs and dosing of alternating polychemotherapy courses R1-3

Drug	Dose	Route	Days drug given
Course R1
Dexamethasone	20 mg/m²	PO	1-5
6-Mercaptopurine	100 mg/m²	PO	1-5
Vincristine	1.5 mg/m²	IV	1, 6
Methotrexate*	1 or 5 g/m²	IV	1
Methotrexate	12 mg	IT	1
Cytarabine	30 mg	IT	1
Prednisone	10 mg	IT	1
Cytarabine	2 g/m² q 12 h	IV	5
l-asparaginase	25 000 U/m²	IM/IV	6
Course R2
Dexamethasone	20 mg/m²	PO	1-5
6-Thioguanine	100 mg/m²	PO	1-5
Vindesine	3 mg/m²	IV	1
Methotrexate*	1 or 5 g/m²	IV	1
Methotrexate	12 mg	IT	1 (and 5)†
Cytarabine	30 mg	IT	1 (and 5)†
Prednisone	10 mg	IT	1 (and 5)†
Daunorubicin	50 mg/m²	IV	5
Ifosfamide	400 mg/m²	IV	1-5
l-asparaginase	25 000 U/m²	IM/IV	6
Course R3
Dexamethasone	20 mg/m²	PO	1-5
Cytarabine	2 g/m² q 12 h	IV	1, 2
Etoposide	150 mg/m²	IV	3-5
Methotrexate	12 mg	IT	5
Cytarabine	30 mg	IT	5
Prednisone	10 mg	IT	5
l-asparaginase	25 000 U/m²	IM/IV	6

Drug	Dose	Route	Days drug given
Course R1
Dexamethasone	20 mg/m²	PO	1-5
6-Mercaptopurine	100 mg/m²	PO	1-5
Vincristine	1.5 mg/m²	IV	1, 6
Methotrexate*	1 or 5 g/m²	IV	1
Methotrexate	12 mg	IT	1
Cytarabine	30 mg	IT	1
Prednisone	10 mg	IT	1
Cytarabine	2 g/m² q 12 h	IV	5
l-asparaginase	25 000 U/m²	IM/IV	6
Course R2
Dexamethasone	20 mg/m²	PO	1-5
6-Thioguanine	100 mg/m²	PO	1-5
Vindesine	3 mg/m²	IV	1
Methotrexate*	1 or 5 g/m²	IV	1
Methotrexate	12 mg	IT	1 (and 5)†
Cytarabine	30 mg	IT	1 (and 5)†
Prednisone	10 mg	IT	1 (and 5)†
Daunorubicin	50 mg/m²	IV	5
Ifosfamide	400 mg/m²	IV	1-5
l-asparaginase	25 000 U/m²	IM/IV	6
Course R3
Dexamethasone	20 mg/m²	PO	1-5
Cytarabine	2 g/m² q 12 h	IV	1, 2
Etoposide	150 mg/m²	IV	3-5
Methotrexate	12 mg	IT	5
Cytarabine	30 mg	IT	5
Prednisone	10 mg	IT	5
l-asparaginase	25 000 U/m²	IM/IV	6

PO indicates by mouth; IV, intravenously; IT, intrathecally; q, every; and IM, intramuscularly.

MTX 1 g/m² and 5 g/m² at a 36- and 24-hour infusion, respectively.

Children with overt meningeal leukemia.