Table 1 Hematologic response criteria... | American Society of Hematology

Table 1

Hematologic response criteria

Major hematologic response

Complete hematologic response
1. WBC count ≤institutional ULN*
2. ANC ≥1000/mm³
3. Platelets ≥100 000/mm³
4. No blasts or promyelocytes in peripheral blood
5. Bone marrow blasts ≤5%
6. <5% myelocytes plus metamyelocytes in peripheral blood
7. Basophils in peripheral blood <20%†
8. No extramedullary involvement (including no hepatomegaly or splenomegaly)
No evidence of leukemia
1. WBC count ≤institutional ULN*
2. No blasts or promyelocytes in peripheral blood
3. Bone marrow blasts ≤5%
4. <5% myelocytes plus metamyelocytes in peripheral blood
5. No extramedullary involvement (including no hepatomegaly or splenomegaly)
6. Basophils in peripheral blood <20%† and at least one of the following:
  - 20 000/mm³ ≤platelets <100 000/mm³
  - 500/mm³ <ANC <1000/mm³

Minor hematologic response

<15% blasts in bone marrow and in peripheral blood
<30% blasts plus promyelocytes in bone marrow and <30% blasts plus promyelocytes in peripheral blood
<20% basophils in peripheral blood
No extramedullary involvement other than spleen and liver

WBC indicates white blood cell; ULN, upper limit of normal; and ANC, absolute neutrophil count.

ULNs were as follows: 1 center 8.0, 1 center 8.8, 1 center 9.0, 6 centers 10.0, 2 centers 10.8, 6 centers 11.0, 1 center 11.1.

As specified in the study protocol.