Clinical and biological parameters associated with risk of progression of MGUS and SMM in the univariate analysis
. | MGUS . | SMM . | ||||
---|---|---|---|---|---|---|
Median PFS, mo . | Progressionno. (%) . | P* . | Median PFS, mo . | Progressionno. (%) . | P* . | |
Immunoparesis | ||||||
None | Nr | 12/266 (4.5) | < .001 | Nr | 8/42 (19) | < .001 |
1 or 2 Ig | 120 | 17/91 (18) | — | 31 | 31/47 (66) | — |
Percentage of BMPC (optical microscope)† | ||||||
Less than 5% or 15% | Nr | 11/251 (4) | .003 | Nr | 17/57 (30) | < .002 |
At least 5% or 15% | Nr | 21/144 (15) | — | 34 | 23/36 (64) | — |
% of BMPC (flow cytometry)‡ | ||||||
Less than 1% or 5% | Nr | 7/196 (3) | < .006 | Nr | 17/64 (26) | < .001 |
At least 1% or 5% | Nr | 25/210 (12) | — | 20 | 22/28 (78) | — |
MC | ||||||
Less than 2 g/dL MGUS and less than 3 g/dL SMM | Nr | 11/279 (4) | < .001 | 84 | 23/64 (36) | .078 |
At least 2 g/dL MGUS and at least 3 g/dL SMM | Nr | 20/111 (18) | — | 31 | 17/29 (58) | — |
Light chain | ||||||
κ | 120 | 23/216 (10) | .02 | 72 | 27/59 (46) | 0.46 |
λ | 9Nr | 6/165 (3) | — | 92 | 13/33 (39) | — |
DNA ploidy | ||||||
Diploid | 120 | 11/172 (6) | .019 | Nr | 11/31 (43) | 0.31 |
Aneuploid | Nr | 18/108 (17) | — | 73 | 21/42 (50) | — |
Bence-Jones proteinuria | ||||||
Less than 0.2 g/24 h | 120 | 10/216 (5) | < .001 | 92 | 26/59 (44) | 0.9 |
At least 0.2 g/24 h | 106 | 7/26 (26) | — | Nr | 2/5 (40) | — |
. | MGUS . | SMM . | ||||
---|---|---|---|---|---|---|
Median PFS, mo . | Progressionno. (%) . | P* . | Median PFS, mo . | Progressionno. (%) . | P* . | |
Immunoparesis | ||||||
None | Nr | 12/266 (4.5) | < .001 | Nr | 8/42 (19) | < .001 |
1 or 2 Ig | 120 | 17/91 (18) | — | 31 | 31/47 (66) | — |
Percentage of BMPC (optical microscope)† | ||||||
Less than 5% or 15% | Nr | 11/251 (4) | .003 | Nr | 17/57 (30) | < .002 |
At least 5% or 15% | Nr | 21/144 (15) | — | 34 | 23/36 (64) | — |
% of BMPC (flow cytometry)‡ | ||||||
Less than 1% or 5% | Nr | 7/196 (3) | < .006 | Nr | 17/64 (26) | < .001 |
At least 1% or 5% | Nr | 25/210 (12) | — | 20 | 22/28 (78) | — |
MC | ||||||
Less than 2 g/dL MGUS and less than 3 g/dL SMM | Nr | 11/279 (4) | < .001 | 84 | 23/64 (36) | .078 |
At least 2 g/dL MGUS and at least 3 g/dL SMM | Nr | 20/111 (18) | — | 31 | 17/29 (58) | — |
Light chain | ||||||
κ | 120 | 23/216 (10) | .02 | 72 | 27/59 (46) | 0.46 |
λ | 9Nr | 6/165 (3) | — | 92 | 13/33 (39) | — |
DNA ploidy | ||||||
Diploid | 120 | 11/172 (6) | .019 | Nr | 11/31 (43) | 0.31 |
Aneuploid | Nr | 18/108 (17) | — | 73 | 21/42 (50) | — |
Bence-Jones proteinuria | ||||||
Less than 0.2 g/24 h | 120 | 10/216 (5) | < .001 | 92 | 26/59 (44) | 0.9 |
At least 0.2 g/24 h | 106 | 7/26 (26) | — | Nr | 2/5 (40) | — |