Table 1 Induction therapy and early... | American Society of Hematology

Table 1

Induction therapy and early intensification for ALL

	Dose	Route	Schedule
Phase 1, weeks 1-4
Daunorubicin	60 mg/m²	IV	Days 1,8,15, and 22
Vincristine	1.4 mg/m²	IV	Days 1,8,15, and 22
Dexamethasone	10 mg/m²	PO	Days 1-5, 11-14
PEG-asparaginase	2000 U/m²	IV	Days 2 and16
Methotrexate	12.5 mg	IT	Day 14
Phase 2, weeks 5-8*
Cyclophosphamide	650 mg/m²	IV	Days 1, 15, and 29
Cytarabine	75 mg/m²	IV	Days 6-9, 13-16, 20-23, and 27-30
6-mercaptopurine	6 mg/m²	PO	Days 1-30
Methotrexate	12.5 mg	IT	Days 1, 8, 15, and 22
Intensification/CNS prophylaxis
Methotrexate	3 g/m²	IV	Days 1 and 8
PEG-asparaginase	2000 U/m²	IV	Day 2

	Dose	Route	Schedule
Phase 1, weeks 1-4
Daunorubicin	60 mg/m²	IV	Days 1,8,15, and 22
Vincristine	1.4 mg/m²	IV	Days 1,8,15, and 22
Dexamethasone	10 mg/m²	PO	Days 1-5, 11-14
PEG-asparaginase	2000 U/m²	IV	Days 2 and16
Methotrexate	12.5 mg	IT	Day 14
Phase 2, weeks 5-8*
Cyclophosphamide	650 mg/m²	IV	Days 1, 15, and 29
Cytarabine	75 mg/m²	IV	Days 6-9, 13-16, 20-23, and 27-30
6-mercaptopurine	6 mg/m²	PO	Days 1-30
Methotrexate	12.5 mg	IT	Days 1, 8, 15, and 22
Intensification/CNS prophylaxis
Methotrexate	3 g/m²	IV	Days 1 and 8
PEG-asparaginase	2000 U/m²	IV	Day 2

IV indicates intravenously; PO, by mouth; and IT, intrathecal.

*Postpone until total WBC count exceeds 3 × 10⁹/L