Table 1 Key rodent malaria infections... | American Society of Hematology

Table 1

Key rodent malaria infections with features of anemia

Plasmodium species/parasite strain/clone	Mouse strain	Features of infection	Features of anemia	Reference no.
P chabaudi chabaudi
AS, CB, AJ, ER	C57BL/6 mice	Nonlethal Sequestration of mature iRBCs	Acute anemia with extravascular hemolysis followed by reticulocytosis after peak parasitemia	36, 66, 82
	A/J	Lethal Sequestration of mature iRBCs	Acute and rapidly progressive anemia	66
P berghei
ANKA	C57BL/6 and CBA/J	Lethal Cerebral syndrome Some sequestration of mature iRBCs	Acute anemia Inadequate reticulocyte response	63, 65
ANKA	BALB/c and DBA/2	Lethal, but also drug induced chronic infection No cerebral syndrome	Chronic anemia in semi-immune mice	57
P berghei	Rat	Lethal	Anemia in splenectomized rats	119
P yoelii
17X	BALB/c SCID	Nonlethal in BALB/c Sequestration of iRBCS in cerebral vessel	Invades only reticulocytes Premature removal of RBC Increased parasitized RBC rigidity	56, 120
17XL	BALB/c	Lethal cerebral syndrome sequestration of iRBCS in cerebral vessel	Can invade RBCs of all ages; acute anemia	112
P vinckei	BALB/c	Lethal	Inhibition of erythropoiesis	121

Plasmodium species/parasite strain/clone	Mouse strain	Features of infection	Features of anemia	Reference no.
P chabaudi chabaudi
AS, CB, AJ, ER	C57BL/6 mice	Nonlethal Sequestration of mature iRBCs	Acute anemia with extravascular hemolysis followed by reticulocytosis after peak parasitemia	36, 66, 82
	A/J	Lethal Sequestration of mature iRBCs	Acute and rapidly progressive anemia	66
P berghei
ANKA	C57BL/6 and CBA/J	Lethal Cerebral syndrome Some sequestration of mature iRBCs	Acute anemia Inadequate reticulocyte response	63, 65
ANKA	BALB/c and DBA/2	Lethal, but also drug induced chronic infection No cerebral syndrome	Chronic anemia in semi-immune mice	57
P berghei	Rat	Lethal	Anemia in splenectomized rats	119
P yoelii
17X	BALB/c SCID	Nonlethal in BALB/c Sequestration of iRBCS in cerebral vessel	Invades only reticulocytes Premature removal of RBC Increased parasitized RBC rigidity	56, 120
17XL	BALB/c	Lethal cerebral syndrome sequestration of iRBCS in cerebral vessel	Can invade RBCs of all ages; acute anemia	112
P vinckei	BALB/c	Lethal	Inhibition of erythropoiesis	121

For more detailed information of mouse models of malaria infection, including immune responses and other pathology, see Lamb et al³¹ and Langhorne et al.³⁸