Antithrombotic treatments and outcomes
| Subject . | Lag to therapy, d . | Treatment group . | Thrombolytic regimen . | Thrombus resolution at 1 y . | PTS physical findings at 18-24 mo . | PTS functional outcome at 18-24 mo . | Major bleeding episodes . |
|---|---|---|---|---|---|---|---|
| 1 | 14 | Thrombolytic regimen | Systemic + local | ≥ 90% resolution, mural thrombus only | None | No chronic LE pain | Pulmonary hemorrhage |
| 2 | 1 | Thrombolytic regimen | Systemic | Complete thrombus resolution | None | No chronic LE pain | None |
| 3 | 7 | Thrombolytic regimen | Local | Complete thrombus resolution | None | Chronic LE pain, limiting aerobic activities | None |
| 4 | 2 | Thrombolytic regimen | Systemic | ≥ 90% resolution, mural thrombus only | None | No chronic LE pain | None |
| 5 | 14 | Thrombolytic regimen | Systemic + local | Complete thrombus resolution | None | No chronic LE pain | None |
| 6 | 2 | Thrombolytic regimen | Systemic | Complete thrombus resolution | None | No chronic LE pain | None |
| 7 | 1 | Thrombolytic regimen | Systemic | Complete thrombus resolution | None | No chronic LE pain | None |
| 8 | 7 | Thrombolytic regimen | Local | Complete thrombus resolution | None | No chronic LE pain | None |
| 9 | 42 | Thrombolytic regimen | Systemic | Persistent thrombosis | E, C, D, U | Chronic LE pain at rest and limiting aerobic activities and ADL | None |
| 10 | 60 | Standard anticoagulation | — | Persistent thrombosis | None | Chronic LE pain, limiting aerobic activities | None |
| 11 | N/A | Standard anticoagulation | — | Persistent thrombosis | None | No chronic LE pain | None |
| 12 | 1 | Standard anticoagulation | — | Complete thrombus resolution | None | No chronic LE pain | None |
| 13 | 7 | Standard anticoagulation | — | Persistent thrombosis | E, C, D | Chronic LE pain at rest and limiting aerobic activities and ADL | None |
| 14 | 14 | Standard anticoagulation | — | Persistent thrombosis | E | Chronic LE pain, limiting aerobic activities | None |
| 15 | 4 | Standard anticoagulation | — | N/A | None | No chronic LE pain | None |
| 16 | 1 | Standard anticoagulation | — | Persistent thrombosis | E, C | Chronic LE pain, limiting aerobic activities and ADL | None |
| 17 | 21 | Standard anticoagulation | — | Persistent thrombosis | E | Chronic LE pain, limiting aerobic activities and ADL | None |
| 18 | 14 | Standard anticoagulation | — | Complete thrombus resolution | E | No chronic LE pain | None |
| 19 | 1 | Standard anticoagulation | — | Complete thrombus resolution | E | No chronic LE pain | None |
| 20 | 3 | Standard anticoagulation | — | ≥ 90% resolution, mural thrombus only | E | No chronic LE pain | None |
| 21 | 1 | Standard anticoagulation | — | Complete thrombus resolution | E | No chronic LE pain | None |
| 22 | 8 | Standard anticoagulation | — | Persistent thrombosis | None | Chronic LE pain, limiting aerobic activities | None |
| Subject . | Lag to therapy, d . | Treatment group . | Thrombolytic regimen . | Thrombus resolution at 1 y . | PTS physical findings at 18-24 mo . | PTS functional outcome at 18-24 mo . | Major bleeding episodes . |
|---|---|---|---|---|---|---|---|
| 1 | 14 | Thrombolytic regimen | Systemic + local | ≥ 90% resolution, mural thrombus only | None | No chronic LE pain | Pulmonary hemorrhage |
| 2 | 1 | Thrombolytic regimen | Systemic | Complete thrombus resolution | None | No chronic LE pain | None |
| 3 | 7 | Thrombolytic regimen | Local | Complete thrombus resolution | None | Chronic LE pain, limiting aerobic activities | None |
| 4 | 2 | Thrombolytic regimen | Systemic | ≥ 90% resolution, mural thrombus only | None | No chronic LE pain | None |
| 5 | 14 | Thrombolytic regimen | Systemic + local | Complete thrombus resolution | None | No chronic LE pain | None |
| 6 | 2 | Thrombolytic regimen | Systemic | Complete thrombus resolution | None | No chronic LE pain | None |
| 7 | 1 | Thrombolytic regimen | Systemic | Complete thrombus resolution | None | No chronic LE pain | None |
| 8 | 7 | Thrombolytic regimen | Local | Complete thrombus resolution | None | No chronic LE pain | None |
| 9 | 42 | Thrombolytic regimen | Systemic | Persistent thrombosis | E, C, D, U | Chronic LE pain at rest and limiting aerobic activities and ADL | None |
| 10 | 60 | Standard anticoagulation | — | Persistent thrombosis | None | Chronic LE pain, limiting aerobic activities | None |
| 11 | N/A | Standard anticoagulation | — | Persistent thrombosis | None | No chronic LE pain | None |
| 12 | 1 | Standard anticoagulation | — | Complete thrombus resolution | None | No chronic LE pain | None |
| 13 | 7 | Standard anticoagulation | — | Persistent thrombosis | E, C, D | Chronic LE pain at rest and limiting aerobic activities and ADL | None |
| 14 | 14 | Standard anticoagulation | — | Persistent thrombosis | E | Chronic LE pain, limiting aerobic activities | None |
| 15 | 4 | Standard anticoagulation | — | N/A | None | No chronic LE pain | None |
| 16 | 1 | Standard anticoagulation | — | Persistent thrombosis | E, C | Chronic LE pain, limiting aerobic activities and ADL | None |
| 17 | 21 | Standard anticoagulation | — | Persistent thrombosis | E | Chronic LE pain, limiting aerobic activities and ADL | None |
| 18 | 14 | Standard anticoagulation | — | Complete thrombus resolution | E | No chronic LE pain | None |
| 19 | 1 | Standard anticoagulation | — | Complete thrombus resolution | E | No chronic LE pain | None |
| 20 | 3 | Standard anticoagulation | — | ≥ 90% resolution, mural thrombus only | E | No chronic LE pain | None |
| 21 | 1 | Standard anticoagulation | — | Complete thrombus resolution | E | No chronic LE pain | None |
| 22 | 8 | Standard anticoagulation | — | Persistent thrombosis | None | Chronic LE pain, limiting aerobic activities | None |
PTS indicates post-thrombotic syndrome; LE, lower extremity; E, edema; C, dilated superficial collateral veins; D, venous stasis dermatitis; U, venous stasis ulcers; ADL, activities of daily living; —, not applicable; N/A, not available.