Patient and thrombus characteristics at diagnosis
| Subject . | Age, y . | DVT site(s) . | Pulmonary embolism . | # Venous segments involved by DVT . | Underlying conditions . | CVC-related . | Genetic thrombophilia . | Treatment group . |
|---|---|---|---|---|---|---|---|---|
| 1 | 9 | IVC, R & L iliac, R femoral | Yes | 4 | Upper respiratory infection | No | None | Thrombolytic regimen |
| 2 | 5 | R femoral | No | 1 | Influenza A, group A Strep sepsis, HUS | Yes | None | Thrombolytic regimen |
| 3 | 15 | L iliac, L femoral | No | 2 | May-Thurner anomaly | No | FV Leiden | Thrombolytic regimen |
| 4 | 7 | IVC, R & L iliac, R femoral | Yes | 4 | Varicella, group A Strep necrotizing | No | PT 20210, ↑ Lp(a) | Thrombolytic regimen |
| 5 | 13 | IVC, R & L iliac, R & L femoral | Yes | 5 | Evan's syndrome | No | PT 20210 | Thrombolytic regimen |
| 6 | 2 | R femoral | No | 1 | Diabetes mellitus, ketoacidosis | Yes | None | Thrombolytic regimen |
| 7 | 1 | L iliac, L femoral | No | 2 | Staph aureus sepsis, osteomyelitis | Yes | None | Thrombolytic regimen |
| 8 | 19 | L iliac | Yes | 1 | May-Thurner anomaly | No | FV Leiden | Thrombolytic regimen |
| 9 | 14 | R & L iliac, R & L femoral | No | 4 | Interrupted IVC, obesity | No | None | Thrombolytic regimen |
| 10 | 14 | IVC, R & L iliac, R femoral | No | 4 | None | No | None | Standard anticoagulation |
| 11 | 11 | IVC, R iliac, R femoral | No | 3 | Down syndrome, OCP, obesity | No | ↑ Lp(a) | Standard anticoagulation |
| 12 | 1 | R femoral | No | 1 | Diabetes mellitus, ketoacidosis | Yes | None | Standard anticoagulation |
| 13 | 13 | IVC, L iliac, L femoral | No | 3 | Surgery, immobilization | No | None | Standard anticoagulation |
| 14 | 11 | IVC, R iliac, R femoral | No | 3 | Positive family history | No | ↑ Lp(a) | Standard anticoagulation |
| 15 | 13 | IVC, R & L iliac | No | 3 | OCP, smoking | No | FV Leiden | Standard anticoagulation |
| 16 | 0.7 | R femoral | No | 1 | Rotavirus gastroenteritis, dehydration | Yes | N/A | Standard anticoagulation |
| 17 | 14 | L femoral, L popliteal | No | 2 | Obesity | No | FV Leiden, ↑ Lp(a) | Standard anticoagulation |
| 18 | 14 | L iliac, L femoral | No | 2 | Lupus | No | None | Standard anticoagulation |
| 19 | 17 | L femoral | No | 1 | Diabetes mellitus, appendicitis | No | None | Standard anticoagulation |
| 20 | 16 | IVC, R iliac, R femoral, R renal | No | 4 | Lupus, avascular necrosis, post-op | No | None | Standard anticoagulation |
| 21 | 13 | L femoral, L popliteal | No | 2 | Diabetes mellitus, ketoacidosis | Yes | None | Standard anticoagulation |
| 22 | 5 | IVC, R & L iliac, L femoral | Yes | 4 | L hip osteomyelitis with abscess | No | None | Standard anticoagulation |
| Subject . | Age, y . | DVT site(s) . | Pulmonary embolism . | # Venous segments involved by DVT . | Underlying conditions . | CVC-related . | Genetic thrombophilia . | Treatment group . |
|---|---|---|---|---|---|---|---|---|
| 1 | 9 | IVC, R & L iliac, R femoral | Yes | 4 | Upper respiratory infection | No | None | Thrombolytic regimen |
| 2 | 5 | R femoral | No | 1 | Influenza A, group A Strep sepsis, HUS | Yes | None | Thrombolytic regimen |
| 3 | 15 | L iliac, L femoral | No | 2 | May-Thurner anomaly | No | FV Leiden | Thrombolytic regimen |
| 4 | 7 | IVC, R & L iliac, R femoral | Yes | 4 | Varicella, group A Strep necrotizing | No | PT 20210, ↑ Lp(a) | Thrombolytic regimen |
| 5 | 13 | IVC, R & L iliac, R & L femoral | Yes | 5 | Evan's syndrome | No | PT 20210 | Thrombolytic regimen |
| 6 | 2 | R femoral | No | 1 | Diabetes mellitus, ketoacidosis | Yes | None | Thrombolytic regimen |
| 7 | 1 | L iliac, L femoral | No | 2 | Staph aureus sepsis, osteomyelitis | Yes | None | Thrombolytic regimen |
| 8 | 19 | L iliac | Yes | 1 | May-Thurner anomaly | No | FV Leiden | Thrombolytic regimen |
| 9 | 14 | R & L iliac, R & L femoral | No | 4 | Interrupted IVC, obesity | No | None | Thrombolytic regimen |
| 10 | 14 | IVC, R & L iliac, R femoral | No | 4 | None | No | None | Standard anticoagulation |
| 11 | 11 | IVC, R iliac, R femoral | No | 3 | Down syndrome, OCP, obesity | No | ↑ Lp(a) | Standard anticoagulation |
| 12 | 1 | R femoral | No | 1 | Diabetes mellitus, ketoacidosis | Yes | None | Standard anticoagulation |
| 13 | 13 | IVC, L iliac, L femoral | No | 3 | Surgery, immobilization | No | None | Standard anticoagulation |
| 14 | 11 | IVC, R iliac, R femoral | No | 3 | Positive family history | No | ↑ Lp(a) | Standard anticoagulation |
| 15 | 13 | IVC, R & L iliac | No | 3 | OCP, smoking | No | FV Leiden | Standard anticoagulation |
| 16 | 0.7 | R femoral | No | 1 | Rotavirus gastroenteritis, dehydration | Yes | N/A | Standard anticoagulation |
| 17 | 14 | L femoral, L popliteal | No | 2 | Obesity | No | FV Leiden, ↑ Lp(a) | Standard anticoagulation |
| 18 | 14 | L iliac, L femoral | No | 2 | Lupus | No | None | Standard anticoagulation |
| 19 | 17 | L femoral | No | 1 | Diabetes mellitus, appendicitis | No | None | Standard anticoagulation |
| 20 | 16 | IVC, R iliac, R femoral, R renal | No | 4 | Lupus, avascular necrosis, post-op | No | None | Standard anticoagulation |
| 21 | 13 | L femoral, L popliteal | No | 2 | Diabetes mellitus, ketoacidosis | Yes | None | Standard anticoagulation |
| 22 | 5 | IVC, R & L iliac, L femoral | Yes | 4 | L hip osteomyelitis with abscess | No | None | Standard anticoagulation |
All genetic mutations were heterozygous.
DVT indicates deep venous thrombosis; CVC, central venous catheter; IVC, inferior vena cava; HUS, hemolytic uremic syndrome; OCP, oral contraceptive pill (standard dose estrogen); post-op, postoperative state with immobility; FV Ledien, factor V Leiden mutation; PT 20210, prothrombin 20210 mutation; ↑ Lp(a), elevated plasma lipoprotein(a) concentration; N/A, not available.