Phosphorylated tyrosine kinases identified by LC-MS/MS in MKPL-1 cells
| Name . | Accession . | Site . | Peptides . |
|---|---|---|---|
| Protein kinase, Tyr (receptor) | |||
| KAEAMLGPSLSPGQDPEGGVDyK | |||
| RKAEAMLGPSLSPGQDPEGGVDyK | |||
| KAEAMLGPSLSPGQDPEGGVDyKNIHLEK | |||
| CSFR | P07333 | 699* | KAEAMLGPSLSPGQDPEGGVDyKNIHLEKK |
| EphB4 | P54760 | 987 | SQAKPGTPGGTGGPAPQy |
| InsR | P06213 | 1185* | |
| InsR iso2 | P06213–2 | 1173* | |
| IGF1R | P08069 | 1161* | DIyETDYyRK |
| InsR | P06213 | 1189* | |
| InsR iso2 | P06213–2 | 1177* | DIYETDyYR |
| IGF1R | P08069 | 1165* | DIYETDyYRK |
| InsR | P06213 | 1190* | |
| InsR iso2 | P06213–2 | 1178* | |
| IGF1R | P08069 | 1166* | DIyETDYyRK |
| Kit | P10721 | 721* | ESSCSDSTNEyMDMKPGVSyVVPTK |
| Kit | P10721 | 730 | ESSCSDSTNEyMDMKPGVSyVVPTK |
| Kit | P10721 | 936* | QISESTNHIySNLANCSPNR |
| Mer | Q12866 | 749* | KIySGDYyR |
| KIySGDYYR | |||
| KIySGDyYR | |||
| Mer | Q12866 | 753* | KIYSGDyYR |
| KIySGDyYR | |||
| Mer | Q12866 | 754* | KIySGDYyR |
| TIE1 | P35590 | 1027 | WMAIESLNySVYTTK |
| KIySGDYyR | |||
| KIySGDYYR | |||
| Tyro3 | Q06418 | 681 | KIySGDyYR |
| KIYSGDyYR | |||
| Tyro3 | Q06418 | 685 | KIySGDyYR |
| Tyro3 | Q06418 | 686 | KIySGDYyR |
| Protein kinase, Tyr (nonreceptor) | |||
| Ack | Q07912 | 518* | KPTyDPVSEDQDPLSSDFKR |
| Ack | Q07912 | 857* | KVSSTHyYLLPERPSYLER |
| Ack | Q07912 | 858* | VSSTHYyLLPERPSYLER |
| VVALyDYMPMNANDLQLR | |||
| Btk | Q06187 | 222* | KVVALyDYMPMNANDLQLR |
| Btk | Q06187 | 224* | VVALYDyMPMNANDLQLR |
| Btk | Q06187 | 343 | HYVVCSTPQSQyYLAEK |
| Btk | Q06187 | 360* | HLFSTIPELINyHQHNSAGLISR |
| Btk | Q06187 | 550* | YVLDDEyTSSVGSKFPVR |
| Fer | P16591 | 714* | QEDGGVySSSGLK |
| Fgr | P09769 | 209 | KLDMGGYyITTR |
| Fyn | P06241 | 212 | |
| Yes | P07947 | 221 | KLDNGGyYITTR |
| Fyn | P06241 | 419* | |
| Yes | P07947 | 425* | |
| Src | P12931 | 418* | LIEDNEyTAR |
| Hck | P08631 | 208* | TLDNGGFyISPR |
| Jak2 | O60674 | 570* | REVGDyGQLHETEVLLK |
| Jak3 | P52333 | 785* | DLNSLISSDyELLSDPTPGALAPR |
| Lck | P06239 | 393* | LIEDNEyTAR |
| P07948 | 193 | SLDNGGYyISPR | |
| Lyn | P07948 | 305 | LyAVVTR |
| Lyn | P07948 | 472* | VENCPDELyDIMK |
| Lyn | P07948 | 396* | VIEDNEyTAR |
| Hck | P08631 | 410* | VIEDNEyTAREGAK |
| Pyk2 | Q14289 | 579* | YIEDEDyYK |
| Syk | P43405 | 323* | QESTVSFNPyEPELAPWAADKGPQR |
| Tyk2 | P29597 | 292* | LLAQAEGEPCyIR |
| Name . | Accession . | Site . | Peptides . |
|---|---|---|---|
| Protein kinase, Tyr (receptor) | |||
| KAEAMLGPSLSPGQDPEGGVDyK | |||
| RKAEAMLGPSLSPGQDPEGGVDyK | |||
| KAEAMLGPSLSPGQDPEGGVDyKNIHLEK | |||
| CSFR | P07333 | 699* | KAEAMLGPSLSPGQDPEGGVDyKNIHLEKK |
| EphB4 | P54760 | 987 | SQAKPGTPGGTGGPAPQy |
| InsR | P06213 | 1185* | |
| InsR iso2 | P06213–2 | 1173* | |
| IGF1R | P08069 | 1161* | DIyETDYyRK |
| InsR | P06213 | 1189* | |
| InsR iso2 | P06213–2 | 1177* | DIYETDyYR |
| IGF1R | P08069 | 1165* | DIYETDyYRK |
| InsR | P06213 | 1190* | |
| InsR iso2 | P06213–2 | 1178* | |
| IGF1R | P08069 | 1166* | DIyETDYyRK |
| Kit | P10721 | 721* | ESSCSDSTNEyMDMKPGVSyVVPTK |
| Kit | P10721 | 730 | ESSCSDSTNEyMDMKPGVSyVVPTK |
| Kit | P10721 | 936* | QISESTNHIySNLANCSPNR |
| Mer | Q12866 | 749* | KIySGDYyR |
| KIySGDYYR | |||
| KIySGDyYR | |||
| Mer | Q12866 | 753* | KIYSGDyYR |
| KIySGDyYR | |||
| Mer | Q12866 | 754* | KIySGDYyR |
| TIE1 | P35590 | 1027 | WMAIESLNySVYTTK |
| KIySGDYyR | |||
| KIySGDYYR | |||
| Tyro3 | Q06418 | 681 | KIySGDyYR |
| KIYSGDyYR | |||
| Tyro3 | Q06418 | 685 | KIySGDyYR |
| Tyro3 | Q06418 | 686 | KIySGDYyR |
| Protein kinase, Tyr (nonreceptor) | |||
| Ack | Q07912 | 518* | KPTyDPVSEDQDPLSSDFKR |
| Ack | Q07912 | 857* | KVSSTHyYLLPERPSYLER |
| Ack | Q07912 | 858* | VSSTHYyLLPERPSYLER |
| VVALyDYMPMNANDLQLR | |||
| Btk | Q06187 | 222* | KVVALyDYMPMNANDLQLR |
| Btk | Q06187 | 224* | VVALYDyMPMNANDLQLR |
| Btk | Q06187 | 343 | HYVVCSTPQSQyYLAEK |
| Btk | Q06187 | 360* | HLFSTIPELINyHQHNSAGLISR |
| Btk | Q06187 | 550* | YVLDDEyTSSVGSKFPVR |
| Fer | P16591 | 714* | QEDGGVySSSGLK |
| Fgr | P09769 | 209 | KLDMGGYyITTR |
| Fyn | P06241 | 212 | |
| Yes | P07947 | 221 | KLDNGGyYITTR |
| Fyn | P06241 | 419* | |
| Yes | P07947 | 425* | |
| Src | P12931 | 418* | LIEDNEyTAR |
| Hck | P08631 | 208* | TLDNGGFyISPR |
| Jak2 | O60674 | 570* | REVGDyGQLHETEVLLK |
| Jak3 | P52333 | 785* | DLNSLISSDyELLSDPTPGALAPR |
| Lck | P06239 | 393* | LIEDNEyTAR |
| P07948 | 193 | SLDNGGYyISPR | |
| Lyn | P07948 | 305 | LyAVVTR |
| Lyn | P07948 | 472* | VENCPDELyDIMK |
| Lyn | P07948 | 396* | VIEDNEyTAR |
| Hck | P08631 | 410* | VIEDNEyTAREGAK |
| Pyk2 | Q14289 | 579* | YIEDEDyYK |
| Syk | P43405 | 323* | QESTVSFNPyEPELAPWAADKGPQR |
| Tyk2 | P29597 | 292* | LLAQAEGEPCyIR |
y in peptide indicates phosphorylated tyrosine residue.
Known phosphorylation site.