Absolute numbers of BM myeloid and erythroid progenitor subsets
| Hematopoietic colony type . | +/+ . | −/− . |
|---|---|---|
| CFU-C (total) | 111 800 ± 21 100 | 59 400 ± 19 800* |
| CFU-GEMM | 8 600 ± 1 900 | 3 800 ± 1 700* |
| CFU-GM | 60 000 ± 11 500 | 34 600 ± 9 100* |
| CFU-G | 16 900 ± 6 300 | 8 400 ± 5 600* |
| CFU-M | 11 100 ± 3 200 | 5 300 ± 3 000* |
| BFU-E | 15 400 ± 7 100 | 7 200 ± 2 600* |
| Hematopoietic colony type . | +/+ . | −/− . |
|---|---|---|
| CFU-C (total) | 111 800 ± 21 100 | 59 400 ± 19 800* |
| CFU-GEMM | 8 600 ± 1 900 | 3 800 ± 1 700* |
| CFU-GM | 60 000 ± 11 500 | 34 600 ± 9 100* |
| CFU-G | 16 900 ± 6 300 | 8 400 ± 5 600* |
| CFU-M | 11 100 ± 3 200 | 5 300 ± 3 000* |
| BFU-E | 15 400 ± 7 100 | 7 200 ± 2 600* |
All assays were performed using methylcellulose medium from Stem Cell Technologies, according to the manufacturer's instructions. Data are the absolute number of CFUs in both hind limbs of 6 mice of each genotype presented as the means plus or minus the standard deviation. Total CFU-C includes all of the subsets as determined by multiplying the progenitor frequency by the BM cellularity. All values were rounded to the nearest 100.
*P < .05 relative to wild-type (+/+).