Table 1 Effect of coagulation proteases... | American Society of Hematology

Table 1

Effect of coagulation proteases and PAR peptide agonists on Golgi TF trafficking

Proteases/peptides	Percent of cells with Golgi TF pool, mean ± SD	Colocalization of TF and golgin-97, correlation coefficient, mean ± SD	TF expression at cell surface, pixel value by image analysis, mean ± SD
Untreated control	83.8 ± 4.50	0.85 ± 0.017	15.9 ± 1.41
FVIIa	23.3 ± 6.12*	0.48 ± 0.053*	25.1 ± 1.15*
FFR-FVIIa	82.9 ± 3.83	0.84 ± 0.022	16.5 ± 1.84
Thrombin	26.0 ± 2.90*	0.42 ± 0.046*	21.6 ± 3.05*
Trypsin	21.0 ± 5.60*	0.48 ± 0.036*	23.5 ± 2.88*
FXa	54.0 ± 8.48*	0.62 ± 0.063*	19.1 ± 3.48*
PAR1 AP	22.2 ± 1.16*	0.44 ± 0.051*	22.3 ± 2.35*
PAR2 AP	25.4 ± 1.56*	0.47 ± 0.027*	22.7 ± 2.59*
PAR3 AP	79.2 ± 3.22	0.78 ± 0.085	16.9 ± 1.04
PAR4 AP	80.5 ±5.15	0.85 ± 0.050	15.8 ± 1.53

Proteases/peptides	Percent of cells with Golgi TF pool, mean ± SD	Colocalization of TF and golgin-97, correlation coefficient, mean ± SD	TF expression at cell surface, pixel value by image analysis, mean ± SD
Untreated control	83.8 ± 4.50	0.85 ± 0.017	15.9 ± 1.41
FVIIa	23.3 ± 6.12*	0.48 ± 0.053*	25.1 ± 1.15*
FFR-FVIIa	82.9 ± 3.83	0.84 ± 0.022	16.5 ± 1.84
Thrombin	26.0 ± 2.90*	0.42 ± 0.046*	21.6 ± 3.05*
Trypsin	21.0 ± 5.60*	0.48 ± 0.036*	23.5 ± 2.88*
FXa	54.0 ± 8.48*	0.62 ± 0.063*	19.1 ± 3.48*
PAR1 AP	22.2 ± 1.16*	0.44 ± 0.051*	22.3 ± 2.35*
PAR2 AP	25.4 ± 1.56*	0.47 ± 0.027*	22.7 ± 2.59*
PAR3 AP	79.2 ± 3.22	0.78 ± 0.085	16.9 ± 1.04
PAR4 AP	80.5 ±5.15	0.85 ± 0.050	15.8 ± 1.53

Values are based on 3 to 7 independent experiments.

Significantly differs from the value obtained with untreated control (P < .01).