Baseline patient characteristics according to Amp1q21 in newly diagnosed MM
. | No. of patients/total no. (%) . | . | . | ||
|---|---|---|---|---|---|
| Characteristics . | No Amp1q21* . | Amp1q21 . | P . | ||
| Age, 65 y or older | 62/274 (23) | 53/205 (26) | .413 | ||
| Female sex | 107/274 (39) | 98/205 (48) | .055 | ||
| White race | 241/274 (88) | 188/205 (92) | .184 | ||
| IgA subtype | 53/274 (19) | 67/201 (33) | < .001 | ||
| B2M level 4 mg/L or more | 68/274 (25) | 78/205 (38) | .002 | ||
| CRP level 4 mg/L or more | 24/274 (9) | 19/205 (9) | .847 | ||
| Creatinine level 2 mg/dL or more | 24/272 (9) | 27/203 (13) | .119 | ||
| LDH level 190 IU/L or more | 67/274 (24) | 81/205 (40) | < .001 | ||
| ALB level less than 3.5 g/dL | 80/265 (30) | 77/198 (39) | .050 | ||
| HGB level less than 10 g/dL | 63/274 (23) | 72/205 (35) | .004 | ||
| CA | 66/253 (26) | 82/187 (44) | < .001 | ||
| Hyperdiploidy† | 35/253 (14) | 44/187 (24) | .009 | ||
| Hypodiploidy† | 16/253 (6) | 36/187 (19) | < .001 | ||
| PC in BM aspirate 33% or more | 107/251 (43) | 76/151 (50) | .133 | ||
| PC in BM biopsy 33% or more | 105/246 (43) | 88/156 (56) | .007 | ||
| del(13)‡ | 37/252 (15) | 67/184 (36) | < .001 | ||
| Focal bone lesions by MRI, 3 or more | 140/265 (53) | 107/196 (55) | .708 | ||
| ISS stage 1 | 140/265 (53) | 73/202 (36) | < .001 | ||
| ISS stage 2 | 83/265 (31) | 73/202 (36) | .274 | ||
| ISS stage 3 | 42/265 (16) | 56/202 (28) | .002 | ||
. | No. of patients/total no. (%) . | . | . | ||
|---|---|---|---|---|---|
| Characteristics . | No Amp1q21* . | Amp1q21 . | P . | ||
| Age, 65 y or older | 62/274 (23) | 53/205 (26) | .413 | ||
| Female sex | 107/274 (39) | 98/205 (48) | .055 | ||
| White race | 241/274 (88) | 188/205 (92) | .184 | ||
| IgA subtype | 53/274 (19) | 67/201 (33) | < .001 | ||
| B2M level 4 mg/L or more | 68/274 (25) | 78/205 (38) | .002 | ||
| CRP level 4 mg/L or more | 24/274 (9) | 19/205 (9) | .847 | ||
| Creatinine level 2 mg/dL or more | 24/272 (9) | 27/203 (13) | .119 | ||
| LDH level 190 IU/L or more | 67/274 (24) | 81/205 (40) | < .001 | ||
| ALB level less than 3.5 g/dL | 80/265 (30) | 77/198 (39) | .050 | ||
| HGB level less than 10 g/dL | 63/274 (23) | 72/205 (35) | .004 | ||
| CA | 66/253 (26) | 82/187 (44) | < .001 | ||
| Hyperdiploidy† | 35/253 (14) | 44/187 (24) | .009 | ||
| Hypodiploidy† | 16/253 (6) | 36/187 (19) | < .001 | ||
| PC in BM aspirate 33% or more | 107/251 (43) | 76/151 (50) | .133 | ||
| PC in BM biopsy 33% or more | 105/246 (43) | 88/156 (56) | .007 | ||
| del(13)‡ | 37/252 (15) | 67/184 (36) | < .001 | ||
| Focal bone lesions by MRI, 3 or more | 140/265 (53) | 107/196 (55) | .708 | ||
| ISS stage 1 | 140/265 (53) | 73/202 (36) | < .001 | ||
| ISS stage 2 | 83/265 (31) | 73/202 (36) | .274 | ||
| ISS stage 3 | 42/265 (16) | 56/202 (28) | .002 | ||
MRI indicates magnetic resonance imaging; other abbreviations are explained in Table 1.
To convert β2-microglobulin level from milligrams per liter to nanomoles per liter, multiply milligrams per liter by 85. To convert creatinine level from milligrams per deciliter to micromoles per liter, multiply milligrams per liter by 88.4. To convert albumin and hemoglobin levels from grams per deciliter to grams per liter, multiply grams per deciliter by 10
Amp1q21: at least 3 copies of 1q21 defined by interphase FISH
Ploidy was defined by G banding
del(13): at least 80% of cells with up to 1 copy of D13S31 by interphase FISH