Predictive factors for thrombosis in patients with HIT treated with lepirudin
. | Thrombosis, no. patients/no. total (%) . | . | Multivariate analysis . | . | . | |||
|---|---|---|---|---|---|---|---|---|
. | Yes . | No . | Odds ratio . | 95% CI . | P . | |||
| Dose of heparin therapy | ||||||||
| Preventive | 4/25 (16.0) | 82/156 (52.6) | 1.00 | NA | NA | |||
| Therapeutic | 21/25 (84.0) | 74/156 (47.4) | 4.26 | 1.32-13.79 | .016 | |||
. | Thrombosis, no. patients/no. total (%) . | . | Multivariate analysis . | . | . | |||
|---|---|---|---|---|---|---|---|---|
. | Yes . | No . | Odds ratio . | 95% CI . | P . | |||
| Dose of heparin therapy | ||||||||
| Preventive | 4/25 (16.0) | 82/156 (52.6) | 1.00 | NA | NA | |||
| Therapeutic | 21/25 (84.0) | 74/156 (47.4) | 4.26 | 1.32-13.79 | .016 | |||
Variables in addition to those listed above were previous treatment with danaparoid, concomitant antiplatelet treatment, lepirudin bolus, platelet count (< 50 × 109/L), and aPTT prolongation 2.5 times baseline value. On multivariate analysis, mean lepirudin dose was not a significant predictive factor for thrombosis. Compared with an odds ratio value of 1 in patients receiving mean lepirudin doses > 0.07 mg/kg/h, the odds ratios (95% confidence interval [CI]) for thrombosis were 0.62 (0.20-1.92; P = .49) and 0.83 (0.28-2.43; P = .93) in patients receiving mean lepirudin doses of 0.04 to 0.07 mg/kg/h and ≤ 0.04 mg/kg/h, respectively
NA indicates not applicable