Toxicity by conditioning regimen
. | No. patients with grade 3 or greater toxicity . | . | . | . | . | |||
|---|---|---|---|---|---|---|---|---|
| . | ATG (3 × 30) + CY (4 × 50) + TBI . | . | . | . | . | |||
| Toxicity* . | 3 × 200 . | 2 × 200 . | 1 × 200 . | CY (2 × 60) + TBI 6 × 200 . | All patients . | |||
| Overall† | 5 (5)/14 | 6 (5)/18 | 5 (2)/46 | 2 (2)/9 | 18 (14)/87 | |||
| Pulmonary | 2 | 4 | 1 | 2 | 9 | |||
| Renal | 2 | 0 | 1 | 0 | 3 | |||
| Oral mucosa | 2 | 0 | 0 | 1 | 2 | |||
| Hepatic | 0 | 0 | 1 | 0 | 1 | |||
| Cardiac | 1 | 0 | 0 | 0 | 1 | |||
| CNS | 0 | 0 | 1 | 0 | 1 | |||
| Multiorgan failure | 1 | 2 | 1 | 0 | 4 | |||
| Urinary tract | 0 | 0 | 1 | 0 | 1 | |||
| Hematologic (TTP) | 0 | 0 | 2 | 0 | 2 | |||
. | No. patients with grade 3 or greater toxicity . | . | . | . | . | |||
|---|---|---|---|---|---|---|---|---|
| . | ATG (3 × 30) + CY (4 × 50) + TBI . | . | . | . | . | |||
| Toxicity* . | 3 × 200 . | 2 × 200 . | 1 × 200 . | CY (2 × 60) + TBI 6 × 200 . | All patients . | |||
| Overall† | 5 (5)/14 | 6 (5)/18 | 5 (2)/46 | 2 (2)/9 | 18 (14)/87 | |||
| Pulmonary | 2 | 4 | 1 | 2 | 9 | |||
| Renal | 2 | 0 | 1 | 0 | 3 | |||
| Oral mucosa | 2 | 0 | 0 | 1 | 2 | |||
| Hepatic | 0 | 0 | 1 | 0 | 1 | |||
| Cardiac | 1 | 0 | 0 | 0 | 1 | |||
| CNS | 0 | 0 | 1 | 0 | 1 | |||
| Multiorgan failure | 1 | 2 | 1 | 0 | 4 | |||
| Urinary tract | 0 | 0 | 1 | 0 | 1 | |||
| Hematologic (TTP) | 0 | 0 | 2 | 0 | 2 | |||
The frequency of toxicities in each column do not add up to the total (overall) because an individual patient may have had more than one organ toxicity.
ATG indicates antithymocyte globulin; CY, cyclophosphamide; TBI, total body irradiation, 3, 2, or 1 × 200 cGy when combined with ATG/CY, or 6 × 200 cGy when combined with CY only; CNS, central nervous system; TTP, thrombotic thrombocytopenic purpura
Severity grade 4 in any organ system or at least grade 3 for pulmonary, oral mucosa (stomatitis), renal, or hepatic toxicity41
Data for the overall row are number of patients with toxicity of grade 3 or greater versus the total number of patients. The numbers of patients with toxicity of grade 3 or greater who died are shown in parentheses