Summary of copy number change in 30 myeloma samples, split into the three groups: t(4;14), t(11;14), and HRD
. | Gain . | . | . | . | Loss . | . | . | . | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Chromosome . | t(4;14) . | t(11;14) . | HRD . | χ2(P) . | t(4;14) . | t(11;14) . | HRD . | χ2(P) . | ||||||
| 1 | +1q [5] | +1q [1] | +1q [5] | 8.15 (.025) | –1p [5] | –1p [1] | –1p [1] | 11.1 (.01) | ||||||
| 2 | – | – | +2 [1] | 1.78 (NS) | – | –2p [1] | – | 1.46 (NS) | ||||||
| 3 | +3 [2], +3q [1] | – | +3 [7] | 10.8 (.01) | – | – | – | – | ||||||
| 4 | +4 [1] | +4 [1] | +4 [1] | 0.19 (NS) | –4 [1] | – | – | 3.4 (NS) | ||||||
| 5 | +5 [2] | – | +5 [5] | 6.7 (.05) | – | – | – | – | ||||||
| 6 | +6 [1], +6p [1] | – | +6p [3] | 4.0 (NS) | –6q [1] | –6q [2] | –6q [1] | 0.29 (NS) | ||||||
| 7 | +7 [1], +7q [1] | – | +7 [5] | 6.7 (.05) | – | – | – | – | ||||||
| 8 | – | – | +8q [1] | 1.78 (NS) | –8p [2] | –8p [1], –8q [1] | –8p [6] | 5.84 (NS) | ||||||
| 9 | +9 [1] | +9q [1] | +9 [8] | 12.2 (.01) | –9p [1] | – | – | 3.39 (NS) | ||||||
| 10 | – | – | – | – | – | – | – | – | ||||||
| 11 | +11 [1] | +11q [3] | +11 [7], +11q [1] | 7.9 (.025) | –11q [1] | – | – | 3.39 (NS) | ||||||
| 12 | – | – | – | – | –12p [2], –12p [1] | – | – | 7 (.05) | ||||||
| 13 | – | – | – | – | –13 [7] | –13 [6] | –13 [2] | 11.45 (.01) | ||||||
| 14 | – | – | – | – | –14q [2] | – | – | 7.0 (.05) | ||||||
| 15 | +15 [4] | – | +15 [9] | 16.35 (.001) | – | – | – | – | ||||||
| 16 | – | – | – | – | – | –16p [1], –16q [4] | –16q [2] | 3.0 (NS) | ||||||
| 17 | – | – | +17 [1], +17p [1] | 3.7 (.2) | –17q [1] | –17p [2] | –17q [1] | 3.2 (NS) | ||||||
| 18 | – | +18 [1] | +18 [1] | 0.67 (NS) | – | – | – | – | ||||||
| 19 | +19 [3] | +19 [3] | +19 [11] | 13.85 (.01) | – | – | – | – | ||||||
| 20 | – | – | +20 [1] | 1.7 (NS) | –20p [1] | – | – | 3.39 (NS) | ||||||
| 21 | +21 [1] | – | – | 3.39 (NS) | –21q [1] | – | – | 3.39 (NS) | ||||||
| 22 | – | – | – | – | –22q [2] | –22q [1] | –22q [1] | 1.87 (NS) | ||||||
| X | +Xq [1] | +Xq [1] | +Xq [1] | 0.18 (NS) | –X [3] | –X [5] | –X [2] | 1.79 (NS) | ||||||
. | Gain . | . | . | . | Loss . | . | . | . | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Chromosome . | t(4;14) . | t(11;14) . | HRD . | χ2(P) . | t(4;14) . | t(11;14) . | HRD . | χ2(P) . | ||||||
| 1 | +1q [5] | +1q [1] | +1q [5] | 8.15 (.025) | –1p [5] | –1p [1] | –1p [1] | 11.1 (.01) | ||||||
| 2 | – | – | +2 [1] | 1.78 (NS) | – | –2p [1] | – | 1.46 (NS) | ||||||
| 3 | +3 [2], +3q [1] | – | +3 [7] | 10.8 (.01) | – | – | – | – | ||||||
| 4 | +4 [1] | +4 [1] | +4 [1] | 0.19 (NS) | –4 [1] | – | – | 3.4 (NS) | ||||||
| 5 | +5 [2] | – | +5 [5] | 6.7 (.05) | – | – | – | – | ||||||
| 6 | +6 [1], +6p [1] | – | +6p [3] | 4.0 (NS) | –6q [1] | –6q [2] | –6q [1] | 0.29 (NS) | ||||||
| 7 | +7 [1], +7q [1] | – | +7 [5] | 6.7 (.05) | – | – | – | – | ||||||
| 8 | – | – | +8q [1] | 1.78 (NS) | –8p [2] | –8p [1], –8q [1] | –8p [6] | 5.84 (NS) | ||||||
| 9 | +9 [1] | +9q [1] | +9 [8] | 12.2 (.01) | –9p [1] | – | – | 3.39 (NS) | ||||||
| 10 | – | – | – | – | – | – | – | – | ||||||
| 11 | +11 [1] | +11q [3] | +11 [7], +11q [1] | 7.9 (.025) | –11q [1] | – | – | 3.39 (NS) | ||||||
| 12 | – | – | – | – | –12p [2], –12p [1] | – | – | 7 (.05) | ||||||
| 13 | – | – | – | – | –13 [7] | –13 [6] | –13 [2] | 11.45 (.01) | ||||||
| 14 | – | – | – | – | –14q [2] | – | – | 7.0 (.05) | ||||||
| 15 | +15 [4] | – | +15 [9] | 16.35 (.001) | – | – | – | – | ||||||
| 16 | – | – | – | – | – | –16p [1], –16q [4] | –16q [2] | 3.0 (NS) | ||||||
| 17 | – | – | +17 [1], +17p [1] | 3.7 (.2) | –17q [1] | –17p [2] | –17q [1] | 3.2 (NS) | ||||||
| 18 | – | +18 [1] | +18 [1] | 0.67 (NS) | – | – | – | – | ||||||
| 19 | +19 [3] | +19 [3] | +19 [11] | 13.85 (.01) | – | – | – | – | ||||||
| 20 | – | – | +20 [1] | 1.7 (NS) | –20p [1] | – | – | 3.39 (NS) | ||||||
| 21 | +21 [1] | – | – | 3.39 (NS) | –21q [1] | – | – | 3.39 (NS) | ||||||
| 22 | – | – | – | – | –22q [2] | –22q [1] | –22q [1] | 1.87 (NS) | ||||||
| X | +Xq [1] | +Xq [1] | +Xq [1] | 0.18 (NS) | –X [3] | –X [5] | –X [2] | 1.79 (NS) | ||||||
Only large regions of chromosomal gain and loss are indicated, with numbers of cases in square brackets. χ2 performed: for significance at P < .05 level, χ2 result should be greater than 5.99. For t(4;14), n = 7; for t(11;14), n = 12; and for HRD, n = 11
HRD indicates hyperdiploid; –, no change; NS, not significant