Summary of chromosomal copy number changes identified by CC, FISH, and CGH
Chromosome . | Lai et al20 CC (% of 66 abnormal)* . | Nilsson et al22 CC (abnormal CC %)* . | Cremer et al18 FISH (%) . | Liebisch et al21 FISH (%) . | Cigudosa et al17 CGH (%) . | Liebisch et al21 CGH (%) . | Gutierrez et al19 CGH (% of 51 abnormal)* . |
|---|---|---|---|---|---|---|---|
| Loss | |||||||
| 1 | NA | 1p (p21-22) (17) | ND | ND | NA | 1p (p21) (13) | 1p (10) |
| 2 | NA | NA | ND | ND | NA | NA | NA |
| 4 | NA | NA | ND | ND | NA | NA | NA |
| 5 | NA | NA | ND | ND | NA | NA | NA |
| 6 | NA | 6q (q21-27) (11) | 6q21 (16) | 6q (21) | 6q (q21) (13) | 6q (15) | 6q (10) |
| 8 | 8 (20) | NA | 8p12 (21) | ND | NA | NA8p (p21) (15) | 8p (10) |
| 10 | 10 (12) | NA | ND | ND | NA | NA | NA |
| 12 | 12 (11) | NA | ND | ND | NA | NA | NA |
| 13 | 13 (33) | 13 (27) | 13q14 (54) | 13q (41) | 13q (q14-21) (30) | 13q (q14-21) (37) | 13q (39) |
| 14 | 14 (20) | 14 (12) | ND | ND | NA | NA | 14q (12) |
| 15 | 15 (12) | NA | ND | ND | NA | NA | NA |
| 16 | NA | 16 (14) | ND | ND | 16 (17) | NA | 16q (18) |
| 17 | NA | NA | 17p13 (26) | ND | NA | NA | NA |
| 20 | 20 (14) | NA | ND | ND | NA | NA | NA |
| 22 | NA | NA | 22q11 (25) | ND | NA | NA | NA |
| X | X (23) | X (17) | ND | ND | NA | X (15) | NA |
| Y | Y (17) | Y (20% males) | ND | ND | NA | NA | Y (12% males) |
| Gain | |||||||
| 1 | NA | 1q (q10-44) (13) | 1q21 (44) | 1p (15) | NA | 1q (q21-23, q25-31) (26) | 1p (10%) 1q (45%) |
| 2 | 2 (11) | NA | ND | ND | NA | NA | NA |
| 3 | 3 (44) | 3 (18) | ND | ND | NA | NA | 3q (16) |
| 4 | NA | 5 (20) | ND | ND | NA | NA | 4q (10) |
| 5 | 5 (26) | NA | ND | ND | NA | 5 (11) | 5q (24) |
| 6 | 6 (11) | NA | ND | 6q (15) | NA | 6p (p21) (11) | 6p (12) |
| 7 | 7 (21) | 7 (19) | ND | ND | NA | NA | 7q (14) |
| 8 | NA | NA | ND | ND | NA | NA | 8q (10) |
| 9 | 9 (39) | 9 (27) | 9q34 (61) | ND | 9q (10) | 9q (q31qter) (15%) 9p (11%) | 9q (24) |
| 11 | 11 (27) | 11 (20) | 11q23 (57) | 11q (42) | 11q (20) | 11q (q23) (15) | 11q (22) |
| 12 | NA | NA | ND | ND | 12q24 (10) | NA | 12q (10) |
| 15 | 15 (29) | 15 (24) | 15q22 (63) | ND | 15q23 (10) | 15 (11) | 15q (22) |
| 17 | NA | NA | ND | 17p (14) | 17q22-24 (10) | NA | 17q (10) |
| 18 | 18 (17) | 18 (10) | ND | ND | NA | 18q (11) | NA |
| 19 | 19 (35) | 19 (22) | 19q13 (61) | ND | 19 (p) (30) | NA | 19q (18) |
| 21 | 21 (17) | 21 (15) | ND | ND | NA | NA | NA |
| 22 | NA | NA | ND | ND | 22q (10) | NA | 22q (10) |
| X | NA | NA | ND | ND | NA | NA | Xq (10) |
Chromosome . | Lai et al20 CC (% of 66 abnormal)* . | Nilsson et al22 CC (abnormal CC %)* . | Cremer et al18 FISH (%) . | Liebisch et al21 FISH (%) . | Cigudosa et al17 CGH (%) . | Liebisch et al21 CGH (%) . | Gutierrez et al19 CGH (% of 51 abnormal)* . |
|---|---|---|---|---|---|---|---|
| Loss | |||||||
| 1 | NA | 1p (p21-22) (17) | ND | ND | NA | 1p (p21) (13) | 1p (10) |
| 2 | NA | NA | ND | ND | NA | NA | NA |
| 4 | NA | NA | ND | ND | NA | NA | NA |
| 5 | NA | NA | ND | ND | NA | NA | NA |
| 6 | NA | 6q (q21-27) (11) | 6q21 (16) | 6q (21) | 6q (q21) (13) | 6q (15) | 6q (10) |
| 8 | 8 (20) | NA | 8p12 (21) | ND | NA | NA8p (p21) (15) | 8p (10) |
| 10 | 10 (12) | NA | ND | ND | NA | NA | NA |
| 12 | 12 (11) | NA | ND | ND | NA | NA | NA |
| 13 | 13 (33) | 13 (27) | 13q14 (54) | 13q (41) | 13q (q14-21) (30) | 13q (q14-21) (37) | 13q (39) |
| 14 | 14 (20) | 14 (12) | ND | ND | NA | NA | 14q (12) |
| 15 | 15 (12) | NA | ND | ND | NA | NA | NA |
| 16 | NA | 16 (14) | ND | ND | 16 (17) | NA | 16q (18) |
| 17 | NA | NA | 17p13 (26) | ND | NA | NA | NA |
| 20 | 20 (14) | NA | ND | ND | NA | NA | NA |
| 22 | NA | NA | 22q11 (25) | ND | NA | NA | NA |
| X | X (23) | X (17) | ND | ND | NA | X (15) | NA |
| Y | Y (17) | Y (20% males) | ND | ND | NA | NA | Y (12% males) |
| Gain | |||||||
| 1 | NA | 1q (q10-44) (13) | 1q21 (44) | 1p (15) | NA | 1q (q21-23, q25-31) (26) | 1p (10%) 1q (45%) |
| 2 | 2 (11) | NA | ND | ND | NA | NA | NA |
| 3 | 3 (44) | 3 (18) | ND | ND | NA | NA | 3q (16) |
| 4 | NA | 5 (20) | ND | ND | NA | NA | 4q (10) |
| 5 | 5 (26) | NA | ND | ND | NA | 5 (11) | 5q (24) |
| 6 | 6 (11) | NA | ND | 6q (15) | NA | 6p (p21) (11) | 6p (12) |
| 7 | 7 (21) | 7 (19) | ND | ND | NA | NA | 7q (14) |
| 8 | NA | NA | ND | ND | NA | NA | 8q (10) |
| 9 | 9 (39) | 9 (27) | 9q34 (61) | ND | 9q (10) | 9q (q31qter) (15%) 9p (11%) | 9q (24) |
| 11 | 11 (27) | 11 (20) | 11q23 (57) | 11q (42) | 11q (20) | 11q (q23) (15) | 11q (22) |
| 12 | NA | NA | ND | ND | 12q24 (10) | NA | 12q (10) |
| 15 | 15 (29) | 15 (24) | 15q22 (63) | ND | 15q23 (10) | 15 (11) | 15q (22) |
| 17 | NA | NA | ND | 17p (14) | 17q22-24 (10) | NA | 17q (10) |
| 18 | 18 (17) | 18 (10) | ND | ND | NA | 18q (11) | NA |
| 19 | 19 (35) | 19 (22) | 19q13 (61) | ND | 19 (p) (30) | NA | 19q (18) |
| 21 | 21 (17) | 21 (15) | ND | ND | NA | NA | NA |
| 22 | NA | NA | ND | ND | 22q (10) | NA | 22q (10) |
| X | NA | NA | ND | ND | NA | NA | Xq (10) |
For Lai et al, n = 129; for Nilsson et al, n = 783; for Cremer et al, n = 81; for Liebisch et al FISH, n = 43; for Cigudosa et al, n = 25; for Liebisch et al CGH, n = 46; and for Gutierrez et al, n = 74
CC indicates conventional cytogenetics; NA, not applicable; ND, not done
Only incidents greater than 10% included