Table 2. Treatment outcomes of 170 adult... | American Society of Hematology

Table 2.

Treatment outcomes of 170 adult AML patients by VxInsight cluster

	A	B	C	D	E	F	P*
No. patients	24	22	31	42	18	33
Disease-free survival
Events	8	3	17	12	5	13	.023
5 y, %†	27	0	6	23	19	32
95% CI, %	6-61	0-71	0-29	2-45	0-52	10-54
HR‡	1.00	2.56	3.58	1.73	1.50	1.25
95% CI	—	0.67-9.81	1.52-8.44	0.71-4.25	0.49-4.59	0.52-3.03
Overall survival
Deaths	18	21	29	34	15	28	.40
5 y, %†	25	5	6	18	15	17
95% CI, %	8-42	0-23	0-15	6-30	0-32	4-30
HR‡	1.00	1.75	1.62	1.21	1.73	1.39
95% CI	—	0.93-3.29	0.90-2.94	0.68-2.15	0.87-3.44	0.77-2.51
Resistant disease
No. (%)	8 (33)	17 (77)	5 (16)	19 (45)	6 (33)	5 (15)	< .001
95% CI, %	16-55	55-92	5-34	30-61	13-59	5-32
CR§	1.00	6.80	0.39	1.65	1.00	0.36
95% CI	—	1.94-27.4	0.10-1.35	0.59-4.86	0.27-3.66	0.09-1.25
Complete response
No. (%)	11 (46)	3 (14)	18 (58)	16 (38)	7 (39)	18 (55)	.023
95% CI, %	26-67	3-35	39-75	24-54	17-64	36-72
CR§	1.00	0.19	1.64	0.73	0.75	1.42
95% CI	—	0.04-0.80	0.56-4.79	0.26-2.01	0.22-2.60	0.49-4.08

	A	B	C	D	E	F	P*
No. patients	24	22	31	42	18	33
Disease-free survival
Events	8	3	17	12	5	13	.023
5 y, %†	27	0	6	23	19	32
95% CI, %	6-61	0-71	0-29	2-45	0-52	10-54
HR‡	1.00	2.56	3.58	1.73	1.50	1.25
95% CI	—	0.67-9.81	1.52-8.44	0.71-4.25	0.49-4.59	0.52-3.03
Overall survival
Deaths	18	21	29	34	15	28	.40
5 y, %†	25	5	6	18	15	17
95% CI, %	8-42	0-23	0-15	6-30	0-32	4-30
HR‡	1.00	1.75	1.62	1.21	1.73	1.39
95% CI	—	0.93-3.29	0.90-2.94	0.68-2.15	0.87-3.44	0.77-2.51
Resistant disease
No. (%)	8 (33)	17 (77)	5 (16)	19 (45)	6 (33)	5 (15)	< .001
95% CI, %	16-55	55-92	5-34	30-61	13-59	5-32
CR§	1.00	6.80	0.39	1.65	1.00	0.36
95% CI	—	1.94-27.4	0.10-1.35	0.59-4.86	0.27-3.66	0.09-1.25
Complete response
No. (%)	11 (46)	3 (14)	18 (58)	16 (38)	7 (39)	18 (55)	.023
95% CI, %	26-67	3-35	39-75	24-54	17-64	36-72
CR§	1.00	0.19	1.64	0.73	0.75	1.42
95% CI	—	0.04-0.80	0.56-4.79	0.26-2.01	0.22-2.60	0.49-4.08

— indicates not applicable.

P value for heterogeneity among 6 clusters based on Pearson χ² test for independence (CR, RD) or log-rank test (OS, DFS).

Kaplan-Meier estimate of probability of OS or DFS at 5 years.

Hazard ratio, relative to cluster A.

Odds ratio, relative to cluster A.