Characteristics of patients with and without CNS leukemia at presentation
Characteristic . | With CNS disease . | Without CNS disease . | P . |
|---|---|---|---|
| Group, no. (%) | < .001 | ||
| MRC | 31 (40) | 932 (65) | |
| ECOG | 46 (60) | 499 (35) | |
| Sex, no. (%) | .2 | ||
| Male | 53 (69) | 878 (61) | |
| Female | 24 (31) | 553 (39) | |
| Ph status, no. (%) | .6 | ||
| Positive | 13 (17) | 263 (18) | |
| Negative | 62 (80) | 1121 (78) | |
| Unknown | 2 (3) | 47 (3) | |
| Median age, y (range) | 29 (16-56) | 31 (14-60) | .8 |
| Median WBC count at diagnosis, × 103/μL (range) | 25.6 (2.7-541.0) | 13.5 (0.6-930.0) | < .001 |
| WBC count more than 30 000/μL at diagnosis, no. (%) | 34 (44) | 494 (35) | .08 |
| Median hemoglobin level at diagnosis, g/dL (range) | 9.8 (3.3-17.3) | 9.3 (2.6-18.2) | .2 |
| Immunophenotype, no. (%) | .001† | ||
| B lineage | 42 (55) | 921 (64) | |
| T cell | 25 (32) | 236 (16) | |
| Mature B cell | 2 (3) | 23 (2) | |
| Other* | 4 (5) | 118 (8) | |
| Unknown | 4 (5) | 133 (9) | |
| Hepatomegaly, no. (%) | 17 (22) | 241 (17) | .3 |
| Splenomegaly, no. (%) | 30 (39) | 410 (29) | .09 |
| Lymph nodes enlarged, no. (%) | 29 (38) | 443 (31) | .3 |
| Mediastinal mass, no. (%) | 16 (21) | 115 (8) | < .001 |
| Remission rates, no. (%) | NS | ||
| Death in induction | 4 (5.2) | 70 (4.9) | |
| Resistant disease | 3 (3.9) | 55 (3.9) | |
| Remitted during phase I | 51 (66.2) | 1019 (71.2) | |
| Remitted during phase II | 11 (14.3) | 157 (11) | |
| Remitted after induction | 7 (9.1) | 86 (6.0) | |
| Unknown | 1 (1.3) | 44 (3.1) |
Characteristic . | With CNS disease . | Without CNS disease . | P . |
|---|---|---|---|
| Group, no. (%) | < .001 | ||
| MRC | 31 (40) | 932 (65) | |
| ECOG | 46 (60) | 499 (35) | |
| Sex, no. (%) | .2 | ||
| Male | 53 (69) | 878 (61) | |
| Female | 24 (31) | 553 (39) | |
| Ph status, no. (%) | .6 | ||
| Positive | 13 (17) | 263 (18) | |
| Negative | 62 (80) | 1121 (78) | |
| Unknown | 2 (3) | 47 (3) | |
| Median age, y (range) | 29 (16-56) | 31 (14-60) | .8 |
| Median WBC count at diagnosis, × 103/μL (range) | 25.6 (2.7-541.0) | 13.5 (0.6-930.0) | < .001 |
| WBC count more than 30 000/μL at diagnosis, no. (%) | 34 (44) | 494 (35) | .08 |
| Median hemoglobin level at diagnosis, g/dL (range) | 9.8 (3.3-17.3) | 9.3 (2.6-18.2) | .2 |
| Immunophenotype, no. (%) | .001† | ||
| B lineage | 42 (55) | 921 (64) | |
| T cell | 25 (32) | 236 (16) | |
| Mature B cell | 2 (3) | 23 (2) | |
| Other* | 4 (5) | 118 (8) | |
| Unknown | 4 (5) | 133 (9) | |
| Hepatomegaly, no. (%) | 17 (22) | 241 (17) | .3 |
| Splenomegaly, no. (%) | 30 (39) | 410 (29) | .09 |
| Lymph nodes enlarged, no. (%) | 29 (38) | 443 (31) | .3 |
| Mediastinal mass, no. (%) | 16 (21) | 115 (8) | < .001 |
| Remission rates, no. (%) | NS | ||
| Death in induction | 4 (5.2) | 70 (4.9) | |
| Resistant disease | 3 (3.9) | 55 (3.9) | |
| Remitted during phase I | 51 (66.2) | 1019 (71.2) | |
| Remitted during phase II | 11 (14.3) | 157 (11) | |
| Remitted after induction | 7 (9.1) | 86 (6.0) | |
| Unknown | 1 (1.3) | 44 (3.1) |
To convert WBC count from × 103 cells per microliter to × 109 cells per liter, multiply × 103 cells per microliter by 1.
To convert hemoglobin level from grams per deciliter to grams per liter, multiply grams per deciliter by 10.
Ph indicates Philadelphia chromosome; NS, not significant.
Biphenotypic null cell, pro—B cell, or other rare type.
B lineage vs T.