Table 1. IC 50 values (nM) of... | American Society of Hematology

Table 1.

IC₅₀ values (nM) of mitoxantrone and imatinib determined by FDA/PI assay in K562, K562/BCRP, and K562/BCRP-MX10 cells

	K562 wild type	K562/BCRP	K562/BCRP-MX10
Mitoxantrone	1.52 ± 0.38 (1.0)	8.35 ± 1.6* (5.5)	10.9 ± 3.8* (7.2)
Imatinib	44.4 ± 5.4 (1.0)	58.7 ± 9.4 (1.3)	89.3 ± 4.7† (2.0)

	K562 wild type	K562/BCRP	K562/BCRP-MX10
Mitoxantrone	1.52 ± 0.38 (1.0)	8.35 ± 1.6* (5.5)	10.9 ± 3.8* (7.2)
Imatinib	44.4 ± 5.4 (1.0)	58.7 ± 9.4 (1.3)	89.3 ± 4.7† (2.0)

Each value represents the mean value ± SEM (n = 4). Relative resistance is shown in parentheses as the ration of the IC₅₀ of K562-expressing BCRP over the IC₅₀ of K562 wild type.

Two-sample t test; P < .05.

†

Two-sample t test; P < .001.

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