Table 2. Biodistribution of AAV6-cFVIII... | American Society of Hematology

Table 2.

Biodistribution of AAV6-cFVIII vector DNA in hemophilia A mice

Tissue	Naive	M1^*	M2^*	M3^*	M4^*	Mean ± SD
Gonad	0.0000	0.0012	0.0007	0.0017	0.0017	0.001 ± 0.000
Liver	0.0000	4.7044	11.3035	5.2088	1.8963	5.778 ± 1.981
Lung	0.0000	0.0004	0.0018	0.0001	0.0060	0.002 ± 0.001
Heart	0.0001	0.0013	0.0042	0.0004	0.0015	0.002 ± 0.001
Kidney	0.0000	0.0075	0.0064	0.0008	0.0010	0.004 ± 0.002
Spleen	0.0002	0.0227	0.0374	0.0217	0.0155	0.024 ± 0.005

Tissue	Naive	M1^*	M2^*	M3^*	M4^*	Mean ± SD
Gonad	0.0000	0.0012	0.0007	0.0017	0.0017	0.001 ± 0.000
Liver	0.0000	4.7044	11.3035	5.2088	1.8963	5.778 ± 1.981
Lung	0.0000	0.0004	0.0018	0.0001	0.0060	0.002 ± 0.001
Heart	0.0001	0.0013	0.0042	0.0004	0.0015	0.002 ± 0.001
Kidney	0.0000	0.0075	0.0064	0.0008	0.0010	0.004 ± 0.002
Spleen	0.0002	0.0227	0.0374	0.0217	0.0155	0.024 ± 0.005

The copy numbers of canine FVIII DNA per diploid genome as determined by QPCR. The limit of detection is 0.0003 copy/diploid genome.

Individual mice dosed with 3 × 10¹¹ vg AAV6-cFVIII.