Causes of treatment-related mortality
Causes of TRM . | Patients, no. (%) . | No. of patients with GVHD . | No. of patients without GVHD . | Early death, no.* . |
|---|---|---|---|---|
| GVHD | 11 (11) | |||
| Infection | 29 (30) | 15 | 8 | 6 |
| Interstitial pneumonitis | 16 (17) | 15 | 0 | 1 |
| Venoocclusive disease | 11 (11) | 5 | 4 | 2 |
| Thrombotic microangiopathy | 8 (8) | 7 | 1 | 0 |
| Heart failure | 7 (7) | 3 | 1 | 3 |
| Hemorrhage | 4 (4) | 3 | 1 | 0 |
| Renal failure | 3 (3) | 2 | 1 | 0 |
| Others† | 9 (9) | 6 | 1 | 2 |
| Total | 98 (100) | 56 | 17 | 14 |
Causes of TRM . | Patients, no. (%) . | No. of patients with GVHD . | No. of patients without GVHD . | Early death, no.* . |
|---|---|---|---|---|
| GVHD | 11 (11) | |||
| Infection | 29 (30) | 15 | 8 | 6 |
| Interstitial pneumonitis | 16 (17) | 15 | 0 | 1 |
| Venoocclusive disease | 11 (11) | 5 | 4 | 2 |
| Thrombotic microangiopathy | 8 (8) | 7 | 1 | 0 |
| Heart failure | 7 (7) | 3 | 1 | 3 |
| Hemorrhage | 4 (4) | 3 | 1 | 0 |
| Renal failure | 3 (3) | 2 | 1 | 0 |
| Others† | 9 (9) | 6 | 1 | 2 |
| Total | 98 (100) | 56 | 17 | 14 |
GVHD indicates graft-versus-host disease.
Early death was defined as treatment-related death before engraftment.
Others (n = 9) were acute respiratory distress syndrome (n = 2), hepatic failure (n = 2), leukoencephalopathy (n = 1), secondary solid cancer (n = 1), suicide (n = 1), and unknown cause (n = 2).