Serum and urine parameters
. | . | . | . | P . | . | . | . | |||
|---|---|---|---|---|---|---|---|---|---|---|
| . | . | . | . | . | Unpaired t test or Bonferroni multiple comparisons test . | . | . | |||
| Group . | A: κ-CHEB/κ-CHEB (n) . | B: κ-CHEB/κ-DEL (n) . | C: controls (n) . | ANOVA . | A vs B . | A vs C . | B vs C . | |||
| Diuresis, μL/min | 1.01 ± 0.6 (13) | ND | 0.81 ± 0.47 (7) | NA | NA | 0.49 | NA | |||
| Serum creatinine, μM | 16.6 ± 5.0 (13) | 19.5 ± 4.3 (11) | 17.9 ± 4.2 (10) | 0.31 | NS | NS | NS | |||
| Serum uric acid, μM | 43.7 ± 20.1 (13) | 57.0 ± 20.7 (11) | 107.6 ± 52.6 (10) | 0.0002 | NS | < 0.001 | < 0.01 | |||
| FE uric acid, % | 14.3 ± 11.0 (10) | 10.6 ± 7.3 (11) | 4.5 ± 3.5 (10) | 0.03 | NS | < 0.05 | NS | |||
| Serum phosphate, mM | 2.1 ± 0.4 (13) | 2.4 ± 0.6 (11) | 3.0 ± 0.4 (10) | 0.003 | NS | < 0.01 | NS | |||
| FE phosphate, % | 23.6 ± 19.1 (9) | 17.9 ± 10.3 (8) | 7.7 ± 3.5 (9) | 0.04 | NS | < 0.05 | NS | |||
| Serum total calcium, mM | 2.38 ± 0.06 (12) | 2.47 ± 0.09 (10) | 2.43 ± 0.10 (10) | 0.11 | NS | NS | NS | |||
| Urine calcium/creatinine, mM/mM | 0.74 ± 0.32 (13) | 0.62 ± 0.39 (11) | 0.81 ± 0.30 (10) | 0.42 | NS | NS | NS | |||
| FE calcium, % | 0.49 ± 0.21 (13) | 0.41 ± 0.20 (10) | 0.58 ± 0.19 (10) | 0.2 | NS | NS | NS | |||
| Urine glucose/creatinine, mM/mM | 0.15 ± 0.1 (12) | 0.15 ± 0.1 (11) | 0.09 ± 0.08 (9) | 0.64 | NS | NS | NS | |||
| Urine CC16/creatinine, μg/g | 756 ± 1496 (13) | ND | 75 ± 30 (7) | NA | NA | 0.008 | NA | |||
. | . | . | . | P . | . | . | . | |||
|---|---|---|---|---|---|---|---|---|---|---|
| . | . | . | . | . | Unpaired t test or Bonferroni multiple comparisons test . | . | . | |||
| Group . | A: κ-CHEB/κ-CHEB (n) . | B: κ-CHEB/κ-DEL (n) . | C: controls (n) . | ANOVA . | A vs B . | A vs C . | B vs C . | |||
| Diuresis, μL/min | 1.01 ± 0.6 (13) | ND | 0.81 ± 0.47 (7) | NA | NA | 0.49 | NA | |||
| Serum creatinine, μM | 16.6 ± 5.0 (13) | 19.5 ± 4.3 (11) | 17.9 ± 4.2 (10) | 0.31 | NS | NS | NS | |||
| Serum uric acid, μM | 43.7 ± 20.1 (13) | 57.0 ± 20.7 (11) | 107.6 ± 52.6 (10) | 0.0002 | NS | < 0.001 | < 0.01 | |||
| FE uric acid, % | 14.3 ± 11.0 (10) | 10.6 ± 7.3 (11) | 4.5 ± 3.5 (10) | 0.03 | NS | < 0.05 | NS | |||
| Serum phosphate, mM | 2.1 ± 0.4 (13) | 2.4 ± 0.6 (11) | 3.0 ± 0.4 (10) | 0.003 | NS | < 0.01 | NS | |||
| FE phosphate, % | 23.6 ± 19.1 (9) | 17.9 ± 10.3 (8) | 7.7 ± 3.5 (9) | 0.04 | NS | < 0.05 | NS | |||
| Serum total calcium, mM | 2.38 ± 0.06 (12) | 2.47 ± 0.09 (10) | 2.43 ± 0.10 (10) | 0.11 | NS | NS | NS | |||
| Urine calcium/creatinine, mM/mM | 0.74 ± 0.32 (13) | 0.62 ± 0.39 (11) | 0.81 ± 0.30 (10) | 0.42 | NS | NS | NS | |||
| FE calcium, % | 0.49 ± 0.21 (13) | 0.41 ± 0.20 (10) | 0.58 ± 0.19 (10) | 0.2 | NS | NS | NS | |||
| Urine glucose/creatinine, mM/mM | 0.15 ± 0.1 (12) | 0.15 ± 0.1 (11) | 0.09 ± 0.08 (9) | 0.64 | NS | NS | NS | |||
| Urine CC16/creatinine, μg/g | 756 ± 1496 (13) | ND | 75 ± 30 (7) | NA | NA | 0.008 | NA | |||
NS indicates not significant; FE, fractional excretion; ND, not done; and NA, not applicable.