ORs and 95% Cls for the combined status of methylenetetrahydrofolate reductase (MTHFR 677 and MTHFR 1298; groups A and B), methionine synthase (MTR A2756G), and thymidylate synthase (TYMS 2R+ and 2R−) genotypes
TS tandem repeats . | MTR A2756G . | MTHFR . | OR . | 95% Cl . | P . |
|---|---|---|---|---|---|
| 2R(+) | AG/GG | — | 1 | Reference | NA |
| 2R(−) | AG/GG | — | 3.76 | 1.355-10.437 | .011* |
| 2R(+) | AA | — | 2.576 | 1.358-4.887 | .004* |
| 2R(−) | AA | — | 4.754 | 2.253-10.032 | <.001* |
| — | AG/GG | Group A | 1 | Reference | NA |
| — | AA | Group A | 2.305 | 1.242-4.278 | .008* |
| — | AG/GG | Group B | 2.406 | 0.866-6.688 | .092 |
| — | AA | Group B | 4.743 | 2.243-10.029 | <.001* |
| 2R(+) | — | Group A | 1 | Reference | NA |
| 2R(−) | — | Group A | 2.122 | 1.231-3.657 | .007* |
| 2R(+) | — | Group B | 2.263 | 1.275-4.018 | .005* |
| 2R(−) | — | Group B | 3.88 | 1.527-9.857 | .004* |
TS tandem repeats . | MTR A2756G . | MTHFR . | OR . | 95% Cl . | P . |
|---|---|---|---|---|---|
| 2R(+) | AG/GG | — | 1 | Reference | NA |
| 2R(−) | AG/GG | — | 3.76 | 1.355-10.437 | .011* |
| 2R(+) | AA | — | 2.576 | 1.358-4.887 | .004* |
| 2R(−) | AA | — | 4.754 | 2.253-10.032 | <.001* |
| — | AG/GG | Group A | 1 | Reference | NA |
| — | AA | Group A | 2.305 | 1.242-4.278 | .008* |
| — | AG/GG | Group B | 2.406 | 0.866-6.688 | .092 |
| — | AA | Group B | 4.743 | 2.243-10.029 | <.001* |
| 2R(+) | — | Group A | 1 | Reference | NA |
| 2R(−) | — | Group A | 2.122 | 1.231-3.657 | .007* |
| 2R(+) | — | Group B | 2.263 | 1.275-4.018 | .005* |
| 2R(−) | — | Group B | 3.88 | 1.527-9.857 | .004* |
NA indicates not applicable.
Statistically significant value.