Number of patients and controls, ORs, and 95% CIs for MTHFR 677 and MTHFR 1298 and combination status of MTHFR 677 and MTHFR 1298
MTHFR 677 . | MTHFR 1298 . | Cases . | Controls . | OR . | 95% CI . | P . |
|---|---|---|---|---|---|---|
| CC* | AA* | 26 | 30 | 1 | Reference | — |
| CC* | AC* | 25 | 45 | 0.641 | 0.313-1.314 | .225 |
| CC* | CC* | 15 | 15 | 1.154 | 0.475-2.804 | .752 |
| CT* | AA* | 37 | 47 | 0.908 | 0.461-1.792 | .782 |
| TT* | AA* | 16 | 24 | 0.769 | 0.338-1.750 | .532 |
| CT | AC | 48 | 35 | 1.582 | 0.800-3.131 | .187 |
| CT | CC | 1 | 0 | — | — | — |
| TT | AC | 3 | 0 | — | — | — |
| TT | CC | 1 | 0 | — | — | — |
| Group A* | — | 119 | 161 | 1 | Reference | — |
| Group B | — | 53 | 35 | 2.049 | 1.257-3.338 | .004* |
MTHFR 677 . | MTHFR 1298 . | Cases . | Controls . | OR . | 95% CI . | P . |
|---|---|---|---|---|---|---|
| CC* | AA* | 26 | 30 | 1 | Reference | — |
| CC* | AC* | 25 | 45 | 0.641 | 0.313-1.314 | .225 |
| CC* | CC* | 15 | 15 | 1.154 | 0.475-2.804 | .752 |
| CT* | AA* | 37 | 47 | 0.908 | 0.461-1.792 | .782 |
| TT* | AA* | 16 | 24 | 0.769 | 0.338-1.750 | .532 |
| CT | AC | 48 | 35 | 1.582 | 0.800-3.131 | .187 |
| CT | CC | 1 | 0 | — | — | — |
| TT | AC | 3 | 0 | — | — | — |
| TT | CC | 1 | 0 | — | — | — |
| Group A* | — | 119 | 161 | 1 | Reference | — |
| Group B | — | 53 | 35 | 2.049 | 1.257-3.338 | .004* |
Group B consists of individuals with at least 1 mutant allele (677CT/1298AC, 677CT/1298CC, 677TT/1298AC, and 677TT/1298CC) of each polymorphism (MTHFR 677 and 1298), thus with a total of 2, 3, or 4 mutant alleles; group A consists of all the other genotypes: 677CC/1298AA, 677CC/1298AC, 677CC/1298CC, 677CT/1298AA, and 677TT/1298AA.
— indicates not applicable.
Genotypes indicated are included in group A.