Number and percentage of patients and controls, ORs, 95% CIs, power to detect the observed OR, and power to detect an OR of 1.5, 2.0, and 2.5 for MTHFR 677 and MTHFR 1298, MTR A2756G, TYMS tandem repeats, and SHMT C1420T
. | . | . | . | . | . | Power to detect, % . | . | . | ||
|---|---|---|---|---|---|---|---|---|---|---|
| Genotype . | No. patients (%) . | No. controls (%) . | OR . | 95% CI . | P . | OR of 1.5 . | OR of 2.0 . | OR of 2.5 . | ||
| MTHFR 677 | ||||||||||
| CC | 66 (38.4) | 92 (45.1) | 1 | Reference | NA | NA | NA | NA | ||
| CT | 86 (50.0) | 88 (43.1) | 1.362 | 0.883-2.102 | .163 | 45 | 88 | 98 | ||
| TT | 20 (11.6) | 24 (11.8) | 1.162 | 0.593-2.276 | .662 | 17 | 44 | 68 | ||
| CT/TT | 106 (61.6) | 112 (54.9) | 1.319 | 0.873-1.994 | .189 | 48 | 89 | 98 | ||
| MTHFR 1298 | ||||||||||
| AA | 79 (45.9) | 102 (51.5) | 1 | Reference | NA | NA | NA | NA | ||
| AC | 76 (44.2) | 81 (40.9) | 1.211 | 0.789-1.861 | .381 | 45 | 88 | 98 | ||
| CC | 17 (9.9) | 15 (7.6) | 1.463 | 0.688-3.110 | .322 | 14 | 34 | 56 | ||
| AC/CC | 93 (54.1) | 96 (48.5) | 1.251 | 0.831-1.884 | .284 | 49 | 91 | 99 | ||
| MTR | ||||||||||
| AA | 144 (84.2) | 149 (72.3) | 1 | Reference | NA | NA | NA | NA | ||
| AG | 24 (14) | 51 (24.8) | 0.487 | 0.285-0.833 | .009 | — | — | — | ||
| GG | 3 (1.8) | 6 (2.9) | 0.517 | 0.127-2.108 | .358 | 10 | 22 | 37 | ||
| AG/GG | 27 (15.8) | 57 (27.7) | 0.49 | 0.294-0.818 | .006 | — | — | — | ||
| SHMT | ||||||||||
| CC | 83 (49.1) | 91 (44.4) | 1 | Reference | NA | NA | NA | NA | ||
| CT | 71 (42) | 94 (45.8) | 0.828 | 0.540-1.271 | .388 | 46 | 88 | 98 | ||
| TT | 15 (8.9) | 20 (9.8) | 0.822 | 0.395-1.711 | .601 | 16 | 40 | 64 | ||
| CT/TT | 86 (50.9) | 114 (55.6) | 0.827 | 0.550-1.244 | .362 | 47 | 89 | 98 | ||
| TYMS R | ||||||||||
| 2R/2R | 36 (22.7) | 78 (38.2) | 1 | Reference | NA | NA | NA | NA | ||
| 2R/3R | 76 (42.0) | 86 (42.2) | 0.529 | 0.320-0.874 | .013 | — | — | — | ||
| 3R/3R | 56 (34.1) | 38 (18.6) | 1.69 | 1.009-2.829 | .046 | — | — | — | ||
| 2R/4R | 1 (1.1) | 1 (0.5) | NA | NA | NA | NA | NA | NA | ||
| 1R/3R | 0 (0.0) | 1 (0.5) | NA | NA | NA | NA | NA | NA | ||
| 2R(+) | 113 (66.9) | 16 (80.9) | 1 | Reference | NA | NA | NA | NA | ||
| 2R(−) | 56 (33.1) | 39 (19.1) | 2.115 | 1.317-3.398 | .002 | — | — | — | ||
. | . | . | . | . | . | Power to detect, % . | . | . | ||
|---|---|---|---|---|---|---|---|---|---|---|
| Genotype . | No. patients (%) . | No. controls (%) . | OR . | 95% CI . | P . | OR of 1.5 . | OR of 2.0 . | OR of 2.5 . | ||
| MTHFR 677 | ||||||||||
| CC | 66 (38.4) | 92 (45.1) | 1 | Reference | NA | NA | NA | NA | ||
| CT | 86 (50.0) | 88 (43.1) | 1.362 | 0.883-2.102 | .163 | 45 | 88 | 98 | ||
| TT | 20 (11.6) | 24 (11.8) | 1.162 | 0.593-2.276 | .662 | 17 | 44 | 68 | ||
| CT/TT | 106 (61.6) | 112 (54.9) | 1.319 | 0.873-1.994 | .189 | 48 | 89 | 98 | ||
| MTHFR 1298 | ||||||||||
| AA | 79 (45.9) | 102 (51.5) | 1 | Reference | NA | NA | NA | NA | ||
| AC | 76 (44.2) | 81 (40.9) | 1.211 | 0.789-1.861 | .381 | 45 | 88 | 98 | ||
| CC | 17 (9.9) | 15 (7.6) | 1.463 | 0.688-3.110 | .322 | 14 | 34 | 56 | ||
| AC/CC | 93 (54.1) | 96 (48.5) | 1.251 | 0.831-1.884 | .284 | 49 | 91 | 99 | ||
| MTR | ||||||||||
| AA | 144 (84.2) | 149 (72.3) | 1 | Reference | NA | NA | NA | NA | ||
| AG | 24 (14) | 51 (24.8) | 0.487 | 0.285-0.833 | .009 | — | — | — | ||
| GG | 3 (1.8) | 6 (2.9) | 0.517 | 0.127-2.108 | .358 | 10 | 22 | 37 | ||
| AG/GG | 27 (15.8) | 57 (27.7) | 0.49 | 0.294-0.818 | .006 | — | — | — | ||
| SHMT | ||||||||||
| CC | 83 (49.1) | 91 (44.4) | 1 | Reference | NA | NA | NA | NA | ||
| CT | 71 (42) | 94 (45.8) | 0.828 | 0.540-1.271 | .388 | 46 | 88 | 98 | ||
| TT | 15 (8.9) | 20 (9.8) | 0.822 | 0.395-1.711 | .601 | 16 | 40 | 64 | ||
| CT/TT | 86 (50.9) | 114 (55.6) | 0.827 | 0.550-1.244 | .362 | 47 | 89 | 98 | ||
| TYMS R | ||||||||||
| 2R/2R | 36 (22.7) | 78 (38.2) | 1 | Reference | NA | NA | NA | NA | ||
| 2R/3R | 76 (42.0) | 86 (42.2) | 0.529 | 0.320-0.874 | .013 | — | — | — | ||
| 3R/3R | 56 (34.1) | 38 (18.6) | 1.69 | 1.009-2.829 | .046 | — | — | — | ||
| 2R/4R | 1 (1.1) | 1 (0.5) | NA | NA | NA | NA | NA | NA | ||
| 1R/3R | 0 (0.0) | 1 (0.5) | NA | NA | NA | NA | NA | NA | ||
| 2R(+) | 113 (66.9) | 16 (80.9) | 1 | Reference | NA | NA | NA | NA | ||
| 2R(−) | 56 (33.1) | 39 (19.1) | 2.115 | 1.317-3.398 | .002 | — | — | — | ||
For patients, n = 172; for controls, n = 204.
NA indicates not applicable; —, not provided when the test was significant.