Table 1.

List of genes up-regulated in MG thymus and significantly decreased in the thymus of corticosteroid-treated patients




MG/A ctrl

MG-t/MG
Classification and GenBank ID
Gene name
FC
FC
P
B-cell related     
    AF044197 CXCL13  2.82   -2.76   .01  
    J03565   Complement component receptor 2 (CD21)   3.00   -2.18   .01  
    AI634950  Immunoglobulin heavy constant mu   5.06   -2.15   .01  
    AF296673  Toll-like receptor 10   2.09   -2.08   .03  
    AL543515  CD74 antigen (invariant polypeptide of MHC, class II)   1.84   -2.07   .01  
    M31732   B-cell CLL/lymphoma 3   1.92   -1.92   .03  
    X12830   Interleukin 6 receptor   2.77   -1.90   .01  
    X66079   Spi-B transcription factor (Spi-1/PU.1 related)   2.06   -1.73   < .001  
    AF062733  Immunoglobulin superfamily, member 4B*  4.43   -1.68   .01  
    M80461   CD79B antigen (immunoglobulin-associated beta)   1.96   -1.68   .006  
    BG822701  CD44 antigen   1.80   -1.54   .01  
    BC001609  Linker for B-cell activation   1.86   -1.38   .01  
    X02882   MHC class II alpha chain gene DZ-alpha   2.04   -1.36   .01  
    BG176768  MHC class II, DO beta   2.43   -1.29   .03  
Transcriptional regulation     
    BG757974  T-cell leukemia/lymphoma 1A   2.84   -2.16   < .001  
    AJ000052  Splicing factor SF1   1.85   -1.91   .01  
    U66615   SWI/SNF complex 155-kDa subunit   1.89   -1.82   .03  
    AW964220  Interferon consensus sequence binding protein 1   2.16   -1.57   .01  
Intracellular signaling     
    S57551   Guanylate cyclase 2C   2.03   -1.93   .03  
    BF026359  Carnitine palmitoyltransferase II   1.80   -1.88   .01  
    NM_002053   Guanylate binding protein 1 (interferon-inducible)   2.50   -1.86   .03  
    BG108304  v-yes-1 Yamaguchi sarcoma viral related oncogene homolog   1.81   -1.66   .03  
    X63128   Activin A receptor, type II   1.85   -1.64   .03  
    BE148534  Serpin B13   1.91   -1.63   .01  
    NM_006849   Protein disulfide isomerase   1.91   -1.59   .01  
Cell signaling     
    U95367   GABA-A receptor pi subunit   1.86   -1.88   .03  
    X51985   Lymphocyte-activation gene 3   2.34   -1.63   .01  
Catalytic activity     
    AB036063  Ribonucleotide reductase M2 B (TP53 inducible)   2.21   -1.87   .01  
    BC000562  2′,5′-oligoadenylate synthetase 1   2.20   -1.67   .001  
    NM_005058   RNA binding motif protein, Y chromosome, family 1, member A1   2.08   -1.59   .01  
    BG567810  Serpin A3*  2.32   -1.41   .03  
Cytoskeleton     
    AB006629  Cytoplasmic linker 2   2.12   -1.71   .01  
Unknown     
    AK022147  TBC1 domain family, member 15   1.83   -1.99   .03  
    AK025023  KIAA0284 protein   2.58   -1.97   .03  
    CAC21785   Unnamed protein   2.20   -1.94   .01  
    AB023187
 
Fibronectin type III domain containing 3
 
2.02
 
-1.70
 
.01
 



MG/A ctrl

MG-t/MG
Classification and GenBank ID
Gene name
FC
FC
P
B-cell related     
    AF044197 CXCL13  2.82   -2.76   .01  
    J03565   Complement component receptor 2 (CD21)   3.00   -2.18   .01  
    AI634950  Immunoglobulin heavy constant mu   5.06   -2.15   .01  
    AF296673  Toll-like receptor 10   2.09   -2.08   .03  
    AL543515  CD74 antigen (invariant polypeptide of MHC, class II)   1.84   -2.07   .01  
    M31732   B-cell CLL/lymphoma 3   1.92   -1.92   .03  
    X12830   Interleukin 6 receptor   2.77   -1.90   .01  
    X66079   Spi-B transcription factor (Spi-1/PU.1 related)   2.06   -1.73   < .001  
    AF062733  Immunoglobulin superfamily, member 4B*  4.43   -1.68   .01  
    M80461   CD79B antigen (immunoglobulin-associated beta)   1.96   -1.68   .006  
    BG822701  CD44 antigen   1.80   -1.54   .01  
    BC001609  Linker for B-cell activation   1.86   -1.38   .01  
    X02882   MHC class II alpha chain gene DZ-alpha   2.04   -1.36   .01  
    BG176768  MHC class II, DO beta   2.43   -1.29   .03  
Transcriptional regulation     
    BG757974  T-cell leukemia/lymphoma 1A   2.84   -2.16   < .001  
    AJ000052  Splicing factor SF1   1.85   -1.91   .01  
    U66615   SWI/SNF complex 155-kDa subunit   1.89   -1.82   .03  
    AW964220  Interferon consensus sequence binding protein 1   2.16   -1.57   .01  
Intracellular signaling     
    S57551   Guanylate cyclase 2C   2.03   -1.93   .03  
    BF026359  Carnitine palmitoyltransferase II   1.80   -1.88   .01  
    NM_002053   Guanylate binding protein 1 (interferon-inducible)   2.50   -1.86   .03  
    BG108304  v-yes-1 Yamaguchi sarcoma viral related oncogene homolog   1.81   -1.66   .03  
    X63128   Activin A receptor, type II   1.85   -1.64   .03  
    BE148534  Serpin B13   1.91   -1.63   .01  
    NM_006849   Protein disulfide isomerase   1.91   -1.59   .01  
Cell signaling     
    U95367   GABA-A receptor pi subunit   1.86   -1.88   .03  
    X51985   Lymphocyte-activation gene 3   2.34   -1.63   .01  
Catalytic activity     
    AB036063  Ribonucleotide reductase M2 B (TP53 inducible)   2.21   -1.87   .01  
    BC000562  2′,5′-oligoadenylate synthetase 1   2.20   -1.67   .001  
    NM_005058   RNA binding motif protein, Y chromosome, family 1, member A1   2.08   -1.59   .01  
    BG567810  Serpin A3*  2.32   -1.41   .03  
Cytoskeleton     
    AB006629  Cytoplasmic linker 2   2.12   -1.71   .01  
Unknown     
    AK022147  TBC1 domain family, member 15   1.83   -1.99   .03  
    AK025023  KIAA0284 protein   2.58   -1.97   .03  
    CAC21785   Unnamed protein   2.20   -1.94   .01  
    AB023187
 
Fibronectin type III domain containing 3
 
2.02
 
-1.70
 
.01
 

Among the 157 up-regulated genes during MG, 36 are significantly down-regulated by glucocorticoids. Genes were identified by Mann-Whitney test on the normalized and centered ratios between MG patients treated by glucocorticoids and untreated MG patients (MG-t/MG). These genes were ranked according to the FC calculated between MG-t and MG and to their function.

*

Genes exhibiting low intensity.

or Create an Account

Close Modal
Close Modal