List of genes up-regulated in MG thymus and significantly decreased in the thymus of corticosteroid-treated patients
. | . | MG/A ctrl . | MG-t/MG . | . | |
|---|---|---|---|---|---|
| Classification and GenBank ID . | Gene name . | FC . | FC . | P . | |
| B-cell related | |||||
| AF044197 | CXCL13 | 2.82 | -2.76 | .01 | |
| J03565 | Complement component receptor 2 (CD21) | 3.00 | -2.18 | .01 | |
| AI634950 | Immunoglobulin heavy constant mu | 5.06 | -2.15 | .01 | |
| AF296673 | Toll-like receptor 10 | 2.09 | -2.08 | .03 | |
| AL543515 | CD74 antigen (invariant polypeptide of MHC, class II) | 1.84 | -2.07 | .01 | |
| M31732 | B-cell CLL/lymphoma 3 | 1.92 | -1.92 | .03 | |
| X12830 | Interleukin 6 receptor | 2.77 | -1.90 | .01 | |
| X66079 | Spi-B transcription factor (Spi-1/PU.1 related) | 2.06 | -1.73 | < .001 | |
| AF062733 | Immunoglobulin superfamily, member 4B* | 4.43 | -1.68 | .01 | |
| M80461 | CD79B antigen (immunoglobulin-associated beta) | 1.96 | -1.68 | .006 | |
| BG822701 | CD44 antigen | 1.80 | -1.54 | .01 | |
| BC001609 | Linker for B-cell activation | 1.86 | -1.38 | .01 | |
| X02882 | MHC class II alpha chain gene DZ-alpha | 2.04 | -1.36 | .01 | |
| BG176768 | MHC class II, DO beta | 2.43 | -1.29 | .03 | |
| Transcriptional regulation | |||||
| BG757974 | T-cell leukemia/lymphoma 1A | 2.84 | -2.16 | < .001 | |
| AJ000052 | Splicing factor SF1 | 1.85 | -1.91 | .01 | |
| U66615 | SWI/SNF complex 155-kDa subunit | 1.89 | -1.82 | .03 | |
| AW964220 | Interferon consensus sequence binding protein 1 | 2.16 | -1.57 | .01 | |
| Intracellular signaling | |||||
| S57551 | Guanylate cyclase 2C | 2.03 | -1.93 | .03 | |
| BF026359 | Carnitine palmitoyltransferase II | 1.80 | -1.88 | .01 | |
| NM_002053 | Guanylate binding protein 1 (interferon-inducible) | 2.50 | -1.86 | .03 | |
| BG108304 | v-yes-1 Yamaguchi sarcoma viral related oncogene homolog | 1.81 | -1.66 | .03 | |
| X63128 | Activin A receptor, type II | 1.85 | -1.64 | .03 | |
| BE148534 | Serpin B13 | 1.91 | -1.63 | .01 | |
| NM_006849 | Protein disulfide isomerase | 1.91 | -1.59 | .01 | |
| Cell signaling | |||||
| U95367 | GABA-A receptor pi subunit | 1.86 | -1.88 | .03 | |
| X51985 | Lymphocyte-activation gene 3 | 2.34 | -1.63 | .01 | |
| Catalytic activity | |||||
| AB036063 | Ribonucleotide reductase M2 B (TP53 inducible) | 2.21 | -1.87 | .01 | |
| BC000562 | 2′,5′-oligoadenylate synthetase 1 | 2.20 | -1.67 | .001 | |
| NM_005058 | RNA binding motif protein, Y chromosome, family 1, member A1 | 2.08 | -1.59 | .01 | |
| BG567810 | Serpin A3* | 2.32 | -1.41 | .03 | |
| Cytoskeleton | |||||
| AB006629 | Cytoplasmic linker 2 | 2.12 | -1.71 | .01 | |
| Unknown | |||||
| AK022147 | TBC1 domain family, member 15 | 1.83 | -1.99 | .03 | |
| AK025023 | KIAA0284 protein | 2.58 | -1.97 | .03 | |
| CAC21785 | Unnamed protein | 2.20 | -1.94 | .01 | |
| AB023187 | Fibronectin type III domain containing 3 | 2.02 | -1.70 | .01 | |
. | . | MG/A ctrl . | MG-t/MG . | . | |
|---|---|---|---|---|---|
| Classification and GenBank ID . | Gene name . | FC . | FC . | P . | |
| B-cell related | |||||
| AF044197 | CXCL13 | 2.82 | -2.76 | .01 | |
| J03565 | Complement component receptor 2 (CD21) | 3.00 | -2.18 | .01 | |
| AI634950 | Immunoglobulin heavy constant mu | 5.06 | -2.15 | .01 | |
| AF296673 | Toll-like receptor 10 | 2.09 | -2.08 | .03 | |
| AL543515 | CD74 antigen (invariant polypeptide of MHC, class II) | 1.84 | -2.07 | .01 | |
| M31732 | B-cell CLL/lymphoma 3 | 1.92 | -1.92 | .03 | |
| X12830 | Interleukin 6 receptor | 2.77 | -1.90 | .01 | |
| X66079 | Spi-B transcription factor (Spi-1/PU.1 related) | 2.06 | -1.73 | < .001 | |
| AF062733 | Immunoglobulin superfamily, member 4B* | 4.43 | -1.68 | .01 | |
| M80461 | CD79B antigen (immunoglobulin-associated beta) | 1.96 | -1.68 | .006 | |
| BG822701 | CD44 antigen | 1.80 | -1.54 | .01 | |
| BC001609 | Linker for B-cell activation | 1.86 | -1.38 | .01 | |
| X02882 | MHC class II alpha chain gene DZ-alpha | 2.04 | -1.36 | .01 | |
| BG176768 | MHC class II, DO beta | 2.43 | -1.29 | .03 | |
| Transcriptional regulation | |||||
| BG757974 | T-cell leukemia/lymphoma 1A | 2.84 | -2.16 | < .001 | |
| AJ000052 | Splicing factor SF1 | 1.85 | -1.91 | .01 | |
| U66615 | SWI/SNF complex 155-kDa subunit | 1.89 | -1.82 | .03 | |
| AW964220 | Interferon consensus sequence binding protein 1 | 2.16 | -1.57 | .01 | |
| Intracellular signaling | |||||
| S57551 | Guanylate cyclase 2C | 2.03 | -1.93 | .03 | |
| BF026359 | Carnitine palmitoyltransferase II | 1.80 | -1.88 | .01 | |
| NM_002053 | Guanylate binding protein 1 (interferon-inducible) | 2.50 | -1.86 | .03 | |
| BG108304 | v-yes-1 Yamaguchi sarcoma viral related oncogene homolog | 1.81 | -1.66 | .03 | |
| X63128 | Activin A receptor, type II | 1.85 | -1.64 | .03 | |
| BE148534 | Serpin B13 | 1.91 | -1.63 | .01 | |
| NM_006849 | Protein disulfide isomerase | 1.91 | -1.59 | .01 | |
| Cell signaling | |||||
| U95367 | GABA-A receptor pi subunit | 1.86 | -1.88 | .03 | |
| X51985 | Lymphocyte-activation gene 3 | 2.34 | -1.63 | .01 | |
| Catalytic activity | |||||
| AB036063 | Ribonucleotide reductase M2 B (TP53 inducible) | 2.21 | -1.87 | .01 | |
| BC000562 | 2′,5′-oligoadenylate synthetase 1 | 2.20 | -1.67 | .001 | |
| NM_005058 | RNA binding motif protein, Y chromosome, family 1, member A1 | 2.08 | -1.59 | .01 | |
| BG567810 | Serpin A3* | 2.32 | -1.41 | .03 | |
| Cytoskeleton | |||||
| AB006629 | Cytoplasmic linker 2 | 2.12 | -1.71 | .01 | |
| Unknown | |||||
| AK022147 | TBC1 domain family, member 15 | 1.83 | -1.99 | .03 | |
| AK025023 | KIAA0284 protein | 2.58 | -1.97 | .03 | |
| CAC21785 | Unnamed protein | 2.20 | -1.94 | .01 | |
| AB023187 | Fibronectin type III domain containing 3 | 2.02 | -1.70 | .01 | |
Among the 157 up-regulated genes during MG, 36 are significantly down-regulated by glucocorticoids. Genes were identified by Mann-Whitney test on the normalized and centered ratios between MG patients treated by glucocorticoids and untreated MG patients (MG-t/MG). These genes were ranked according to the FC calculated between MG-t and MG and to their function.
Genes exhibiting low intensity.